An experimental study about the application of Gadolinium oxide nanoparticles in magnetic theranostics

被引：14

作者：

Alizadeh, Mohammad Javad ^{[1
]}

Kariminezhad, Hasan ^{[1
]}

Monfared, Ali Shabestani ^{[2
]}

Mostafazadeh, Amrollah ^{[3
]}

Amani, Hossein ^{[4
]}

Niksirat, Fatemeh ^{[2
]}

Pourbagher, Roghayeh ^{[3
]}

机构：

[1] Noshirvani Univ Technol, Dept Phys, Fac Basic Sci, POB 47148-71167, Babol Sar, Iran

[2] Babol Univ Med Sci, Sch Med, Dept Med Phys Radiobiol & Radiat Protect, POB 47176-47745, Babol Sar, Iran

[3] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, POB 47176-47745, Babol Sar, Iran

[4] Babol Noshirvani Univ Technol, Fac Chem Engn, POB 47148-71167, Babol Sar, Iran

来源：

MATERIALS RESEARCH EXPRESS | 2019年 / 6卷 / 06期

关键词：

gadolinium oxide nanoparticles; gadolinium chelate; contrast agent; MRI; magnetic hyperthermia; GD2O3; NANOPARTICLES; CONTRAST AGENTS; IN-VIVO; HYPERTHERMIA;

D O I：

10.1088/2053-1591/ab0ce3

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In this paper, based on comparing magnetisms, relaxation time, magnetic resonance images (MRI) and the magnetic hyperthermia, the ability of Gadolinium oxide (Gd2O3) nanoparticles for theranostics purposes was investigated. For this, Gd2O3 nanoparticles in 10 and 5 nm sizes were synthesized using DEG and PVP stabilizers, respectively. According to VSM results, these nanoparticles are superparamagnetic and had one hundred times smaller relaxation time in comparison with commercial Gadolinium chelates. In RPMI 1640, compared to Dotarem and Gadovist as two clinical Gadolinium chalets, T1-weighted images proved the superiority of Gd2O3 nanoparticles in contrast production at concentrations ranging from 0.025 to 0.1 mM. In addition, induction of a 200 kHz alternating magnetic field for 240 s was led to a temperature growth similar to 12 degrees C and 14 degrees C for 10 and 5 nm nanoparticles, respectively. These outstanding magnetic properties of Gd2O3 nanoparticles are likely attributed to their size and these nanoparticles therefore are proposed as novel theranostices agents for more researches about magnetic theranostics.

引用

页数：10

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