An experimental study about the application of Gadolinium oxide nanoparticles in magnetic theranostics

In this paper, based on comparing magnetisms, relaxation time, magnetic resonance images (MRI) and the magnetic hyperthermia, the ability of Gadolinium oxide (Gd2O3) nanoparticles for theranostics purposes was investigated. For this, Gd2O3 nanoparticles in 10 and 5 nm sizes were synthesized using DEG and PVP stabilizers, respectively. According to VSM results, these nanoparticles are superparamagnetic and had one hundred times smaller relaxation time in comparison with commercial Gadolinium chelates. In RPMI 1640, compared to Dotarem and Gadovist as two clinical Gadolinium chalets, T1-weighted images proved the superiority of Gd2O3 nanoparticles in contrast production at concentrations ranging from 0.025 to 0.1 mM. In addition, induction of a 200 kHz alternating magnetic field for 240 s was led to a temperature growth similar to 12 degrees C and 14 degrees C for 10 and 5 nm nanoparticles, respectively. These outstanding magnetic properties of Gd2O3 nanoparticles are likely attributed to their size and these nanoparticles therefore are proposed as novel theranostices agents for more researches about magnetic theranostics.