Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin

被引：250
作者：
Li, Xiaoqiang [1 ,2 ,3 ]
Kanjwal, Muzafar A. [1 ]
Lin, Lin [4 ]
Chronakis, Ioannis S. [1 ]
机构：
[1] Tech Univ Denmark, DTU Food, DK-2800 Lyngby, Denmark
[2] Jiangnan Univ, Key Lab Sci & Technol Ecotext, Minist Educ, Wuxi 214122, Peoples R China
[3] Jiangnan Univ, Coll Text & Clothing, Wuxi 214122, Peoples R China
[4] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 103卷
关键词：
Fast-dissolving drug delivery systems; Burst release; Electrospinning; PVA; DRUG-DELIVERY; CONTROLLED-RELEASE; FIBERS; MATS; SCAFFOLD; DISSOLUTION; MEMBRANES; COLLAGEN; TABLETS; CELLS;
D O I：
10.1016/j.colsurfb.2012.10.016
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Fast-dissolving drug delivery systems were prepared by electrospinning using polyvinyl alcohol (PVA) as the filament-forming polymer and drug carrier. Caffeine and riboflavin were used as the model drugs. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction were applied to investigate the physicochemical properties of electrospun nanofibers. The SEM images showed that nanofibers prepared from electrospinning PVA/drug aqueous solutions possessed an ultrafine morphology with an average diameter in the range of 260-370 nm. Pharmacotechnical tests showed that PVA/caffeine and PVA/riboflavin nanofibrous mats had almost the same dissolution time (about 1.5 s) and wetting time (about 4.5 s). The release measurements indicated that drugs can be released in a burst manner (caffeine to an extent of 100% and riboflavin to an extent of 40% within 60 s) from the PVA nanofibrous matrices. (c) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：182 / 188
页数：7
相关论文
共 39 条
[1]   Synthesis, characterization and surface properties of amphiphilic polystyrene-b-polypropylene glycol block copolymers [J].
Alli, A ;
Hazer, B ;
Menceloglu, Y ;
Süzer, E .
EUROPEAN POLYMER JOURNAL, 2006, 42 (04) :740-750
[2]   Electrospinning of keratin/poly(ethylene oxide) blend nanofibers [J].
Aluigi, A. ;
Varesano, A. ;
Montarsolo, A. ;
Vineis, C. ;
Ferrero, F. ;
Mazzuchetti, G. ;
Tonin, C. .
JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 104 (02) :863-870
[3]   Control of an electrospinning jet using electric focusing and jet-steering fields [J].
Bellan, Leon M. ;
Craighead, H. G. .
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 2006, 24 (06) :3179-3183
[4]   Tailoring tissue engineering scaffolds using electrostatic processing techniques: A study of poly(glycolic acid) electrospinning [J].
Boland, ED ;
Wnek, GE ;
Simpson, DG ;
Pawlowski, KJ ;
Bowlin, GL .
JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY, 2001, 38 (12) :1231-1243
[5]   Electrospinning of collagen and elastin for tissue engineering applications [J].
Buttafoco, L ;
Kolkman, NG ;
Engbers-Buijtenhuijs, P ;
Poot, AA ;
Dijkstra, PJ ;
Vermes, I ;
Feijen, J .
BIOMATERIALS, 2006, 27 (05) :724-734
[6]   Functionalizing electrospun fibers with biologically relevant macromolecules [J].
Casper, CL ;
Yamaguchi, N ;
Kiick, KL ;
Rabolt, JF .
BIOMACROMOLECULES, 2005, 6 (04) :1998-2007
[7]   Modeling and comparison of dissolution profiles [J].
Costa, P ;
Manuel, J ;
Lobo, S .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 13 (02) :123-133
[8]   Investigation of drug release and matrix degradation of electrospun poly(DL-lactide) fibers with paracetanol inoculation [J].
Cui, Wenguo ;
Li, Xiaohong ;
Zhu, Xinli ;
Yu, Guo ;
Zhou, Shaobing ;
Weng, Jie .
BIOMACROMOLECULES, 2006, 7 (05) :1623-1629
[9]   MECHANISMS OF DISSOLUTION OF FRUSEMIDE PVP SOLID DISPERSIONS [J].
DOHERTY, C ;
YORK, P .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 34 (03) :197-205
[10]   Orally fast disintegrating tablets: Developments, technologies, taste-masking and clinical studies [J].
Fu, YR ;
Yang, SC ;
Jeong, SH ;
Kimura, S ;
Park, K .
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2004, 21 (06) :433-475
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