Structure-activity relationship studies for multitarget antithrombotic drugs

被引：8
作者：
Neves, Ana R. [1 ]
Correia-da-Silva, Marta [1 ,2 ]
Sousa, Emilia [1 ,2 ]
Pinto, Madalena [1 ,2 ]
机构：
[1] Univ Porto, Fac Pharm, Dept Chem Sci, Organ Chem & Pharmaceut Lab, Rua Jorge Viterbo Ferreira 228, P-4050313 Oporto, Portugal
[2] Univ Porto, Interdisciplinary Ctr Marine & Environm Res CIIMA, Rua Bragas 289, P-4050123 Oporto, Portugal
来源：
FUTURE MEDICINAL CHEMISTRY | 2016年 / 8卷 / 18期
关键词：
anticoagulant; antiplatelet; multitarget; structure-activity relationships; thrombosis; THROMBOXANE SYNTHASE INHIBITOR; DUAL ANTIPLATELET THERAPY; FACTOR-XA; RECEPTOR ANTAGONIST; A(2) RECEPTOR; SULFATED FLAVONOIDS; FACTORS IXA; THROMBIN INHIBITORS; PLASMA KALLIKREIN; AUSTRALIAN SPONGE;
D O I：
10.4155/fmc-2015-0020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Thrombosis is a complex process involving multiple pathways. Currently, therapy relies on the combination of two or more antithrombotic drugs, showing that inhibiting more than one target provides benefits in the prevention and treatment of thrombosis. This review focuses on structure-activity relationship studies of molecules possessing multiple actions against thrombosis, namely, dual inhibitors of coagulation, dual inhibitors of coagulation and platelet aggregation, and also dual inhibitors of platelet aggregation. EP217609 has just entered clinical trials, which raise the expectations on the multitarget strategy to prevent or treat thrombosis.
引用
收藏
页码：2305 / 2355
页数：51
相关论文
共 116 条
  • [71] Antithrombotic agents from hematophagous animals
    Markwardt, F
    [J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 1996, 2 (02) : 75 - 82
  • [72] Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages
    Matsuda, H
    Kageura, T
    Oda, M
    Morikawa, T
    Sakamoto, Y
    Yoshikawa, M
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (06) : 716 - 720
  • [73] Mearns BM, 2011, NAT REV CARDIOL, V8, P179, DOI [10.1038/nrcardio.2011.93, 10.1038/nrcardio.2011.109, 10.1038/nrcardio.2011.88, 10.1038/nrcardio.2011.42, 10.1038/nrcardio.2011.126, 10.1038/nrcardio.2011.52, 10.1038/nrcardio.2011.55]
  • [74] Mederski W, 2002, [No title captured], Patent No. [WO02070471, 02070471]
  • [75] Mederski W, 2002, [No title captured], Patent No. [WO0210127, 0210127]
  • [76] Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin
    Mehta, A. Y.
    Mohammed, B. M.
    Martin, E. J.
    Brophy, D. F.
    Gailani, D.
    Desai, U. R.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2016, 14 (04) : 828 - 838
  • [77] Targeting the GPlbα Binding Site of Thrombin To Simultaneously Induce Dual Anticoagulant and Antiplatelet Effects
    Mehta, Akul Y.
    Thakkar, Jay N.
    Mohammed, Bassem M.
    Martin, Erika J.
    Brophy, Donald F.
    Kishimoto, Takao
    Desai, Umesh R.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (07) : 3030 - 3039
  • [78] Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study
    Mehta, SR
    Yusuf, S
    Peters, RJG
    Bertrand, ME
    Lewis, BS
    Natarajan, MK
    Maimberg, K
    Rupprecht, HJ
    Zhao, F
    Chrolavicius, S
    Copland, I
    Fox, KAA
    [J]. LANCET, 2001, 358 (9281) : 527 - 533
  • [79] 5-Chlorothiophene-2-carboxylic Acid [(S)-2-[2-Methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor
    Meneyrol, Jerome
    Follmann, Markus
    Lassalle, Gilbert
    Wehner, Volkmar
    Barre, Guillaume
    Rousseaux, Tristan
    Altenburger, Jean-Michel
    Petit, Frederic
    Bocskei, Zsolt
    Schreuder, Herman
    Alet, Nathalie
    Herault, Jean-Pascal
    Millet, Laurence
    Dol, Frederique
    Florian, Peter
    Schaeffer, Paul
    Sadoun, Freddy
    Klieber, Sylvie
    Briot, Christophe
    Bono, Francoise
    Herbert, Jean-Marc
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (23) : 9441 - 9456
  • [80] From magic bullets to designed multiple ligands
    Morphy, R
    Kay, C
    Rankovic, Z
    [J]. DRUG DISCOVERY TODAY, 2004, 9 (15) : 641 - 651
3456789101112