Structure-activity relationship studies for multitarget antithrombotic drugs

被引：8

作者：

Neves, Ana R. ^{[1
]}

Correia-da-Silva, Marta ^{[1
,2
]}

Sousa, Emilia ^{[1
,2
]}

Pinto, Madalena ^{[1
,2
]}

机构：

[1] Univ Porto, Fac Pharm, Dept Chem Sci, Organ Chem & Pharmaceut Lab, Rua Jorge Viterbo Ferreira 228, P-4050313 Oporto, Portugal

[2] Univ Porto, Interdisciplinary Ctr Marine & Environm Res CIIMA, Rua Bragas 289, P-4050123 Oporto, Portugal

来源：

FUTURE MEDICINAL CHEMISTRY | 2016年 / 8卷 / 18期

关键词：

anticoagulant; antiplatelet; multitarget; structure-activity relationships; thrombosis; THROMBOXANE SYNTHASE INHIBITOR; DUAL ANTIPLATELET THERAPY; FACTOR-XA; RECEPTOR ANTAGONIST; A(2) RECEPTOR; SULFATED FLAVONOIDS; FACTORS IXA; THROMBIN INHIBITORS; PLASMA KALLIKREIN; AUSTRALIAN SPONGE;

D O I：

10.4155/fmc-2015-0020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thrombosis is a complex process involving multiple pathways. Currently, therapy relies on the combination of two or more antithrombotic drugs, showing that inhibiting more than one target provides benefits in the prevention and treatment of thrombosis. This review focuses on structure-activity relationship studies of molecules possessing multiple actions against thrombosis, namely, dual inhibitors of coagulation, dual inhibitors of coagulation and platelet aggregation, and also dual inhibitors of platelet aggregation. EP217609 has just entered clinical trials, which raise the expectations on the multitarget strategy to prevent or treat thrombosis.

引用

页码：2305 / 2355

页数：51

共 116 条

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