Clonal analysis of stem cells in differentiation and disease

被引：10

作者：

Colom, Bartomeu ^{[1
]}

Jones, Philip H. ^{[1
,2
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

[2] Univ Cambridge, MRC Canc Unit, Hutchison MRC Res Ctr, Box 197,Cambridge Biomed Campus, Cambridge CB2 0XZ, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2016年 / 43卷

基金：

英国惠康基金;

关键词：

PROGENITOR CELLS; INTESTINAL CRYPT; INTERFOLLICULAR EPIDERMIS; SOMATIC MUTATIONS; WOUND REPAIR; FIELD CHANGE; IN-VIVO; HOMEOSTASIS; POPULATIONS; FOLLICLE;

D O I：

10.1016/j.ceb.2016.07.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tracking the fate of individual cells and their progeny by clonal analysis has redefined the concept of stem cells and their role in health and disease. The maintenance of cell turnover in adult tissues is achieved by the collective action of populations of stem cells with an equal likelihood of self-renewal or differentiation. Following injury stem cells exhibit striking plasticity, switching from homeostatic behavior in order to repair damaged tissues. The effects of disease states on stem cells are also being uncovered, with new insights into how somatic mutations trigger clonal expansion in early neoplasia.

引用

页码：14 / 21

页数：8

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