Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)

被引：31

作者：

Fuursted, Kurt ^{[1
]}

Scholer, Lone ^{[4
]}

Hansen, Frank ^{[2
,3
]}

Dam, Karen ^{[5
]}

Bojer, Martin S. ^{[6
,7
]}

Hammerum, Anette M. ^{[2
,3
]}

Dagnaes-Hansen, Frederik ^{[5
]}

Olsen, Anders ^{[4
]}

Jasemian, Yousef ^{[5
]}

Struve, Carsten ^{[6
]}

机构：

[1] Aarhus Univ Hosp, Dept Clin Microbiol, DK-8200 Aarhus N, Denmark

[2] Statens Serum Inst, Antimicrobial Resistance Reference Lab, Dept Microbiol Surveillance & Res, DK-2300 Copenhagen S, Denmark

[3] Statens Serum Inst, Surveillance Unit, Dept Microbiol Surveillance & Res, DK-2300 Copenhagen S, Denmark

[4] Aarhus Univ, Dept Mol Biol, DK-8000 Aarhus C, Denmark

[5] Aarhus Univ, Dept Biomed, DK-8000 Aarhus C, Denmark

[6] Statens Serum Inst, Unit Gastrointestinal Infect, Dept Microbiol Surveillance & Res, DK-2300 Copenhagen S, Denmark

[7] Roskilde Univ, Dept Sci Syst & Models, DK-4000 Roskilde, Denmark

来源：

MICROBES AND INFECTION | 2012年 / 14卷 / 02期

关键词：

Klebsiella pneumoniae; New Delhi metallo-beta-lactamase-1; Virulence; Animal study; Caenorhabditis elegans; CAENORHABDITIS-ELEGANS; LIVER-ABSCESS; COMPLICATIONS; RESISTANCE;

D O I：

10.1016/j.micinf.2011.08.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：155 / 158

页数：4

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