Involvement of estrogen receptors in prostatic diseases

被引：25

作者：

Kawashima, Hidenori ^{[1
]}

Nakatani, Tatsuya ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Urol, Abeno Ku, Osaka 5458585, Japan

来源：

INTERNATIONAL JOURNAL OF UROLOGY | 2012年 / 19卷 / 06期

关键词：

benign prostatic hyperplasia; estrogen receptors alpha and ss; pathogenesis; prostate cancer; therapeutic target; CANCER-CELL-MIGRATION; BETA ER-BETA; EPITHELIAL-CELLS; STROMAL CELLS; DIFFERENTIAL EXPRESSION; ANDROGEN RECEPTOR; IN-VITRO; DEPENDENT EXPRESSION; TUMOR PROGRESSION; GENE-EXPRESSION;

D O I：

10.1111/j.1442-2042.2012.02987.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Accumulating evidence shows that estrogens participate in the pathogenesis and development of benign prostatic hyperplasia and prostate cancer by activating estrogen receptor a. In contrast, estrogen receptor beta is involved in the differentiation and maturation of prostatic epithelial cells, and thus possesses antitumor effects in prostate cancer. However, the natural ligands of estrogen receptor beta are not fully understood, and its mode of action according to its ligands and the binding sites located in the promoter regions of downstream genes remains to be elucidated. Here, we review recent experimental investigations of estrogen receptors and their urological relevance. Estrogen receptor-mediated signaling in the prostate is essential together with the androgen receptor-mediated pathway, providing a new therapeutic target for prostatic diseases.

引用

页码：512 / 522

页数：11

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