In vivo H-1 MRS choline: Correlation with in vitro chemistry histology

被引：295

作者：

Miller, BL

Chang, L

Booth, R

Ernst, T

Cornford, M

Nikas, D

McBride, D

Jenden, DJ

机构：

[1] UNIV CALIF LOS ANGELES,HARBOR MED CTR,DEPT RADIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,HARBOR MED CTR,DEPT PATHOL,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,HARBOR MED CTR,DEPT NEUROSURG,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,DEPT MOLEC & MED PHARMACOL,LOS ANGELES,CA

来源：

LIFE SCIENCES | 1996年 / 58卷 / 22期

关键词：

H-1 magnetic resonance spectroscopy; choline; brain;

D O I：

10.1016/0024-3205(96)00182-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We correlated the in vivo H-1 Magnetic Resonance Spectroscopy (MRS) concentration of the choline peak (CHO) with in vitrochemical measures of choline-containing compounds and a histological grade of cellularity in 18 patients with neoplastic and infectious brain lesions. Gas-chromatography-mass-spectrometry (GCMS) was used to measure the concentrations of free choline (Cho), glycerophosphocholine (GPCho), phosphocholine (PCho) and phosphatidylcholine (PtdCho) from biopsies in the same area where MRS was performed. Cellular density, free Cho, PCho and GPCho were the strongest determinants of H-1 MRS CHO while PtdCho was not. Just as the H-1 MRS 2.0 peak reflects both the concentration of n-acetyl-1-aspartate and neuronal density, the H-1 MRS 3.2 peak reflects the concentration of water-soluble choline-containing compounds and cellular density.

引用

页码：1929 / 1935

页数：7

共 14 条

[1] METABOLISM OF HUMAN GLIOMAS - ASSESSMENT WITH H-1 MR SPECTROSCOPY AND F-18 FLUORODEOXYGLUCOSE PET [J].