Association of plasma cyclooxygenase-2 levels and genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults

被引:18
作者
Wang, Yang [1 ,2 ]
Zhou, Qing [3 ,4 ]
Gao, Wei-Hua [5 ]
Yan, Yu [1 ,2 ]
Chu, Chao [1 ,2 ]
Chen, Chen [1 ]
Yuan, Yue [1 ,2 ]
Wang, Ke-Ke [1 ,2 ]
Ma, Qiong [1 ,2 ]
Gao, Ke [1 ]
Hu, Jia-Wen [1 ]
Liao, Yue-Yuan [1 ,2 ]
Li, Min [1 ]
Sun, Yue [1 ]
Chang, John [6 ,7 ]
Zhang, Jie [8 ]
Xu, Jing-Tao [1 ]
Wang, Dan [1 ]
Zang, Wei-Jin [9 ]
Mu, Jian-Jun [1 ,2 ]
机构
[1] Xi An Jiao Tong Univ, Dept Cardiovasc Med, Affiliated Hosp 1, Xian, Peoples R China
[2] Key Lab Mol Cardiol Shaanxi Prov, Xian, Peoples R China
[3] Natl Engn Res Ctr Beijing Biochip Technol, Beijing, Peoples R China
[4] CapitalBio Corp, Beijing, Peoples R China
[5] Xian 1 Hosp, Dept Cardiol, Xian, Peoples R China
[6] Yale Sch Med, Dept Med, New Haven, CT USA
[7] Vet Adm Healthcare Syst, Dept Med, West Haven, CT USA
[8] Xian Fourth Peoples Hosp, Dept Cardiol, Xian, Peoples R China
[9] Xi An Jiao Tong Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Basic Med Sci, Xian, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
blood pressure; COX-2; gene polymorphism; salt sensitivity; salt; DIETARY SALT; POTASSIUM INTERVENTIONS; CYCLO-OXYGENASE-2; INHIBITION; PTGS2; POLYMORPHISMS; VARIANTS; EXPRESSION; RESPONSES; SODIUM; COX-2; SUPPLEMENTATION;
D O I
10.1097/HJH.0000000000002473
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objective: Cyclooxygenase (COX)-2, an inducible isoform of the major rate-limiting enzymes that regulate the production of prostaglandins is associated with injury, inflammation and proliferation. We sought to examine whether plasma COX-2 levels and its genetic variants is associated with salt sensitivity, BP changes and/or hypertension in humans. Methods: Eighty participants (aged 18-65 years) were maintained sequentially either on a usual diet for 3 days, a low-salt diet (3.0 g) for 7 days, and a high-salt diet (18.0 g) for an additional 7 days. In addition, we studied participants of the original Baoji Salt-Sensitive Study, recruited from 124 families from seven Chinese villages in 2004 who received the same salt intake intervention, and evaluated them for the development of hypertension. Results: Plasma COX-2 levels were significantly decreased with reduction of salt intake from the usual to a low-salt diet and decreased further when converting from the low-salt to the high-salt diet. SNPs rs12042763 in theCOX-2gene was significantly associated with SBP responses to both low-salt and high-salt diet. SNPs rs689466 and rs12042763 were significantly associated with longitudinal changes in BPs. In addition, several COX-2 SNPs were significantly associated with incident hypertension over an 8-year follow-up. Gene-based analyses also supported the overall association of COX-2 with longitudinal changes in SBP and hypertension incidence. Conclusion: This study shows that dietary salt intake affects plasma COX-2 levels and that COX-2 may play a role in salt sensitivity, BP progression and development of hypertension in the Chinese populations studied.
引用
收藏
页码:1745 / 1754
页数:10
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