Voltage-gated sodium channels and pain-related disorders

被引：19

作者：

Kanellopoulos, Alexandros H. ^{[1
]}

Matsuyama, Ayako ^{[1
]}

机构：

[1] UCL, Wolfson Inst Biomed Res, Mol Nocicept Grp, Gower St, London WC1E 6BT, England

来源：

CLINICAL SCIENCE | 2016年 / 130卷 / 24期

关键词：

heritable disorders; Nav1.7; pain; voltage-gated sodium channels; OF-FUNCTION MUTATIONS; CLOSED-STATE INACTIVATION; INFLAMMATORY PAIN; NEUROPATHIC PAIN; SCN9A MUTATIONS; RAMP CURRENTS; MICE LACKING; NA(V)1.7; ERYTHROMELALGIA; EXCITABILITY;

D O I：

10.1042/CS20160041

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Voltage-gated sodium channels (VGSCs) are heteromeric transmembrane protein complexes. Nine homologous members, SCN1A-11A, make up the VGSC gene family. Sodium channel isoforms display a wide range of kinetic properties endowing different neuronal types with distinctly varied firing properties. Among the VGSCs isoforms, Nav1.7, Nav1.8 and Nav1.9 are preferentially expressed in the peripheral nervous system. These isoforms are known to be crucial in the conduction of nociceptive stimuli with mutations in these channels thought to be the underlying cause of a variety of heritable pain disorders. This review provides an overview of the current literature concerning the role of VGSCs in the generation of pain and heritable pain disorders.

引用

页码：2257 / 2265

页数：9

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