Enantioselective Construction of Highly Substituted Vinylidenecylopentanes by Palladium-Catalyzed Asymmetric [3+2] Cycloaddition Reaction

被引：45
作者：
Trost, Barry M. [1 ]
Maruniak, Autumn [1 ]
机构：
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 24期
基金：
美国国家科学基金会;
关键词：
3+2] cycloaddition; allenes; asymmetric catalysis; palladium; trimethylenemethane; ESTER SURROGATES; N-ACYLPYRROLES; TRIMETHYLENEMETHANE; PYRROLIDINES; ADDITIONS; LIGANDS; ALLENES; IMINES;
D O I：
10.1002/anie.201300275
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new cycloadduct: The title reaction of methylene-trimethylenemethane (TMM) with α,β-unsaturated N-acyl pyrroles is an efficient method for the construction of vinylidenecyclopentanes. An asymmetric protocol using this unique donor forms cycloadducts in excellent yield and enantioselectivity, making use of a bisdiamidophosphite ligand derived from trans-1,2- stilbenediamine. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：6262 / 6264
页数：3
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