Enantioselective Construction of Highly Substituted Vinylidenecylopentanes by Palladium-Catalyzed Asymmetric [3+2] Cycloaddition Reaction

被引：45

作者：

Trost, Barry M. ^{[1
]}

Maruniak, Autumn ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 24期

基金：

美国国家科学基金会;

关键词：

3+2] cycloaddition; allenes; asymmetric catalysis; palladium; trimethylenemethane; ESTER SURROGATES; N-ACYLPYRROLES; TRIMETHYLENEMETHANE; PYRROLIDINES; ADDITIONS; LIGANDS; ALLENES; IMINES;

D O I：

10.1002/anie.201300275

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new cycloadduct: The title reaction of methylene-trimethylenemethane (TMM) with α,β-unsaturated N-acyl pyrroles is an efficient method for the construction of vinylidenecyclopentanes. An asymmetric protocol using this unique donor forms cycloadducts in excellent yield and enantioselectivity, making use of a bisdiamidophosphite ligand derived from trans-1,2- stilbenediamine. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6262 / 6264

页数：3

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