Smad2 and Smad4 gene mutations in hepatocellular carcinoma

被引：144
|
作者：
Yakicier, MC
Irmak, MB
Romano, A
Kew, M
Ozturk, M [1 ]
机构：
[1] Bilkent Univ, Dept Mol Biol & Genet, TR-06533 Ankara, Turkey
[2] Univ Witwatersrand, Johannesburg, South Africa
来源：
ONCOGENE | 1999年 / 18卷 / 34期
关键词：
hepatocellular carcinoma; Smad2; Smad4; TGF beta; tumor suppressor genes; somatic mutation;
D O I：
10.1038/sj.onc.1202866
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TGF-beta is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-beta pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4 (Asp332Gly and Cys401Arg) and one in Smad2 (Gln407Arg) genes. All three mutations were A:T --> G:C transitions suspected to result from oxidative stress as observed in mitochondrial DNA. These observation demonstrate that TGF-beta pathway is altered in hepatocellular carcinoma.
引用
收藏
页码：4879 / 4883
页数：5
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