Carotid baroreceptors are mainly localized in the medial portions of the proximal internal carotid artery

被引：23

作者：

Toorop, Raechel J. ^{[1
]}

Ousrout, Rkia ^{[2
]}

Scheltinga, Marc R. M. ^{[3
]}

Moll, Frans L. ^{[1
]}

Bleys, Ronald L. A. W. ^{[2
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Vasc Surg, NL-3508 GA Utrecht, Netherlands

[2] Univ Med Ctr, Dept Anat, Utrecht, Netherlands

[3] Maxima Med Ctr, Dept Surg, Veldhoven, Netherlands

来源：

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2013年 / 195卷 / 03期

关键词：

Carotid sinus syndrome; Carotid denervation; Adventitial stripping; Baroreceptors; Immunohistochemistry; Vesicular glutamate transporter 2; Protein gene product 9.5; VESICULAR GLUTAMATE TRANSPORTER-2; PRODUCT PGP 9.5; SINUS SYNDROME; NEUROENDOCRINE CELLS; INNERVATION; MARKER; BIFURCATION; EXPRESSION; TERMINALS; NEURONS;

D O I：

10.1016/j.aanat.2012.12.001

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Aim: To visualize baroreceptors in the human carotid bifurcation by light microscopy. Baroreceptor location is investigated in order to provide recommendations for the extent of adventitial stripping in the treatment for carotid sinus syndrome (CSS). Methods: Human carotid specimens were transversely cut in 20 pm sections. After immunohistochemical staining using antibodies to vesicular glutamate transporter 2 (VGLUT2) and protein gene product 9.5 (PGP 9.5), the presence of baroreceptor tissue was studied using light microscopic techniques. Results: Visual assessment indicated that VGLUT2 and PGP 9.5 immunoreactivity was present in the adventitia of the carotid arteries and that nerve density was highest in the medial wall of the proximal first cm of the internal carotid artery (ICA). Conclusion: Human carotid baroreceptors, as reflected in immunoreactivity for VGLUT2 and PGP 9.5, are mainly localized in the medial portions of the proximal ICA. If surgical carotid denervation is indicated in patients suffering from carotid sinus syndrome, adventitial stripping of the proximal portion of the ICA should be sufficient. (c) 2013 Elsevier GmbH. All rights reserved.

引用

页码：248 / 252

页数：5

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