The role of miRNAs in cardiovascular disease risk factors

被引：50
作者：
Buie, Joy N. Jones [1 ]
Goodwin, Andrew J. [2 ]
Cook, James A. [3 ]
Halushka, Perry V. [4 ]
Fan, Hongkuan [1 ]
机构：
[1] Med Univ South Carolina, Dept Pathol & Lab Med, 173 Ashley Ave,Suite CRI 605B, Charleston, SC 29425 USA
[2] Med Univ South Carolina, Div Pulm Crit Care Allergy & Sleep Med, Charleston, SC USA
[3] Med Univ South Carolina, Dept Neurosci, Charleston, SC USA
[4] Med Univ South Carolina, Dept Pharmacol, Charleston, SC USA
来源：
ATHEROSCLEROSIS | 2016年 / 254卷
基金：
美国国家卫生研究院;
关键词：
miRNA; Cardiovascular disease; Coronary artery disease; Risk factors; Review; TRIGLYCERIDE TRANSFER PROTEIN; CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; MICRORNA EXPRESSION; ANTISENSE OLIGONUCLEOTIDES; LIPOPROTEIN METABOLISM; CIRCULATING MICRORNAS; CIGARETTE-SMOKING; GENE-EXPRESSION; MESSENGER-RNA;
D O I：
10.1016/j.atherosclerosis.2016.09.067
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Coronary artery disease and atherosclerosis are complex pathologies that develop over time due to genetic and environmental factors. Differential expression of miRNAs has been identified in patients with coronary artery disease and atherosclerosis, however, their association with cardiovascular disease risk factors, including hyperlipidemia, hypertension, obesity, diabetes, lack of physical activity and smoking, remains unclear. This review examines the role of miRNAs as either biomarkers or potential contributors to the pathophysiology of these aforementioned risk factors. It is intended to provide an overview of the published literature which describes alterations in miRNA levels in both human and animal studies of cardiovascular risk factors and when known, the possible mechanism by which these miRNAs may exert either beneficial or deleterious effects. The intent of this review is engage clinical, translational, and basic scientists to design future collaborative studies to further elucidate the potential role of miRNAs in cardiovascular diseases. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：271 / 281
页数：11
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