Research Progress inAstragalus Membranaceusand Its Active Components on Immune Responses in Liver Fibrosis

被引：19
作者：
Liu Yu-tong [1 ]
Lv Wen-liang [2 ]
机构：
[1] Shaanxi Univ Tradit Chinese Med, Xianyang 712046, Shaanxi, Peoples R China
[2] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Infect, Beijing 100053, Peoples R China
来源：
CHINESE JOURNAL OF INTEGRATIVE MEDICINE | 2020年 / 26卷 / 10期
基金：
中国国家自然科学基金;
关键词：
liver fibrosis; immune cell; Astragalus membranaceus; review; NF-KAPPA-B; HEPATIC STELLATE CELLS; SINUSOIDAL ENDOTHELIAL-CELLS; ASTRAGALUS POLYSACCHARIDES; TOTAL FLAVONOIDS; TNF-ALPHA; OXIDATIVE STRESS; UP-REGULATION; MECHANISMS; RATS;
D O I：
10.1007/s11655-019-3039-1
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The interaction between immune cells and hepatic stellate cells (HSCs) can modulate the development of hepatic fibrosis. It can also regulate hepatic fibrosis and liver cirrhosis caused by excessive deposition of extracellular matrix (ECM). This article reviews the action mechanism of immune cells on liver fibrosis and the effect ofAstragalus membranaeusand its active components on immune cells. In-depth study of interaction between immune cells and HSCs on the pathogenesis of liver fibrosis, and the regulatory effect ofAstragalus membranaeusand its active components on immune mechanism will provide new insights in the treatment of liver fibrosis.
引用
收藏
页码：794 / 800
页数：7
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