Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β-catenin pathway

被引：13
作者：
Zhang, Wei-long [1 ,2 ]
Wang, Sha-sha [2 ,3 ]
Jiang, Ya-ping [1 ,2 ,4 ]
Liu, Yan [2 ,3 ]
Yu, Xiang-hua [2 ,3 ]
Wu, Jing-biao [2 ,3 ]
Wang, Ke [2 ,3 ]
Pang, Xin [2 ,3 ]
Liao, Peng [2 ,3 ]
Liang, Xin-hua [2 ,3 ]
Tang, Ya-ling [1 ,2 ]
机构：
[1] Sichuan Univ, State Key Lab Oral Dis, Dept Oral Pathol, West China Hosp Stomatol, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Dept Oral & Maxillofacial Surg, Chengdu, Sichuan, Peoples R China
[4] Qingdao Univ, Affiliated Hosp, Dept Implant, Qingdao, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 19期
基金：
中国国家自然科学基金;
关键词：
epithelial-mesenchymal transition; fatty acid synthase; PRRX1; salivary adenoid cystic carcinoma; Wnt/beta-catenin; CANCER CELL; METABOLISM; METASTASIS; INHIBITION; EXPRESSION; PRRX1; FASN; PROLIFERATION; GROWTH; EMT;
D O I：
10.1111/jcmm.15760
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Fatty acid synthase (FASN) has been shown to be selectively up-regulated in cancer cells to drive the development of cancer. However, the role and associated mechanism of FASN in regulating the malignant progression of salivary adenoid cystic carcinoma (SACC) still remains unclear. In this study, we demonstrated that FASN inhibition attenuated invasion, metastasis and EMT of SACC cells as well as the expression ofPRRX1, ZEB1, Twist, Slug and Snail, among which the level of PRRX1 changed the most obviously. Overexpression of PRRX1 restored migration and invasion in FASN knockdown cells, indicating that PRRX1 is an important downstream target of FASN signalling. Levels of cyclin D1 and c-Myc, targets of Wnt/beta-catenin pathway, were significantly decreased by FASN silencing and restored by PRRX1 overexpression. In addition, FASN expression was positively associated with metastasis and poor prognosis of SACC patients as well as with the expression of PRRX1, cyclin D1 and c-Myc in SACC tissues. Our findings revealed that FASN in SACC progression may induce EMT in a PRRX1/Wnt/beta-catenin dependent manner.
引用
收藏
页码：11465 / 11476
页数：12
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