Preliminary Study on Gelation of Succinylated Poly(Pro-Hyp-Gly) and Chitosan by Polyion Complex Interaction for Cartilage Repair

被引：0

作者：

Kusumastuti, Y. ^{[1
]}

Shibasaki, Y. ^{[1
]}

Hirohara, S. ^{[1
]}

Terada, K. ^{[1
]}

Ando, T. ^{[1
]}

Tanihara, M. ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Ikoma, Japan

来源：

5TH EUROPEAN CONFERENCE OF THE INTERNATIONAL FEDERATION FOR MEDICAL AND BIOLOGICAL ENGINEERING, PTS 1 AND 2 | 2012年 / 37卷

关键词：

Polyion complex; succinylated poly(Pro-Hyp-Gly); chitosan; cartilage; gelation; SCAFFOLDS; COLLAGEN;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The research focusing on injectable material for tissue engineering has encouraged the investigation of gel formation derived from succinylated poly(Pro-Hyp-Gly) and chitosan. This paper describes a preliminary study on gelation of both materials to obtain a new material for cartilage repair. Poly(Pro-Hyp-Gly) shows a collagen-like triple helical structure as a major component of extracellular matrix of cartilage. Furthermore, the cationic nature of chitosan is similar in chemical structure with various glycosaminoglicans in cartilage. Through polyion complex interaction between carboxy group of succinylated poly(Pro-Hyp-Gly) and amino group of chitosan, viscous solution containing gel particles was obtained.

引用

页码：1070 / 1073

页数：4

共 11 条

[1] Collagens -: major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair [J].