Practical Synthesis of Pioglitazone: Ligand Substitution Reaction With Oxido Vanadium(IV) and Biological Activity

被引：6

作者：

Altun, Ozlen ^{[1
]}

Kucuktepe, Caner ^{[2
]}

Yoruk, Ozan ^{[1
]}

Feyizoglu, Adilhan ^{[1
]}

机构：

[1] Trakya Univ, Dept Chem, TR-22030 Edirne, Turkey

[2] ZENTIVA, Luleburgaz Kirklareli, Turkey

来源：

SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY | 2013年 / 43卷 / 03期

关键词：

biological activity; Mg; methanol; oxidovanadium(IV); pioglitazone; spectroscopy; REDUCTION; DISPOSITION; MAGNESIUM; COMPLEXES; CHEMISTRY;

D O I：

10.1080/15533174.2012.740708

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The authors performed two types of experiments: the reduction of 5-{4-[2-(5-ethyl-2-pyridyl)etoxy]benzilidine}-24- thiazolidinedione to pioglitazone (5-{4-[2-(5-ethyl-2-pyridyl) etoxy]benzil}-24-thiazolidinedione) with magnesium/methanol and the synthesis of an oxidovanadium(IV) complex of pioglitazone in methanol under refluxing conditions. The structures of pioglitazone and its oxidovanadium(IV) complex were analyzed by using physicochemical and spectroscopic techniques. Comparisons of the spectral measurements of pioglitazone with those of its oxidovanadium(IV) ion complex are useful in determining the atoms of the ligand that are coordinated to the metal ion. In addition, antibacterial and antifungal activities of the complex were studied and the complex is screened against bacteria and fungi.

引用

页码：221 / 225

页数：5

共 23 条

[1]

[Anonymous], 2001, MERCK INDEX PIOGLITA, P7537

[2]

BALHAUSEN CJ, 1965, MOL ORBITAL THEORY

[3] Coordination asymmetry in μ-oxido divanadium complexes: Development of synthetic protocols [J].