Nitric oxide rescues thalidomide mediated teratogenicity

被引：49

作者：

Siamwala, Jamila H. ^{[1
]}

Veeriah, Vimal ^{[1
]}

Priya, M. Krishna ^{[1
]}

Rajendran, Saranya ^{[1
]}

Saran, Uttara ^{[1
]}

Sinha, Swaraj ^{[1
]}

Nagarajan, Shunmugam ^{[1
]}

Pradeep, T. ^{[1
]}

Chatterjee, Suvro ^{[1
]}

机构：

[1] Anna Univ, Vasc Biol Lab, AU KBC Res Ctr, Madras 600025, Tamil Nadu, India

来源：

SCIENTIFIC REPORTS | 2012年 / 2卷

关键词：

ANGIOGENESIS; DERIVATIVES; APOPTOSIS;

D O I：

10.1038/srep00679

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thalidomide, a sedative drug given to pregnant women, unfortunately caused limb deformities in thousands of babies. Recently the drug was revived because of its therapeutic potential; however the search is still ongoing for an antidote against thalidomide induced limb deformities. In the current study we found that nitric oxide (NO) rescues thalidomide affected chick (Gallus gallus) and zebrafish (Danio rerio) embryos. This study confirms that NO reduced the number of thalidomide mediated limb deformities by 94% and 80% in chick and zebrafish embryos respectively. NO prevents limb deformities by promoting angiogenesis, reducing oxidative stress and inactivating caspase-3 dependent apoptosis. We conclude that NO secures angiogenesis in the thalidomide treated embryos to protect them from deformities.

引用

页数：10

共 43 条

[1] Thalidomide inhibits interferon-γ-mediated nitric oxide production in mouse vascular endothelial cells [J].

Badamtseren, Battuvshin ;

Odkhuu, Erdenezaya ;

Koide, Naoki ;

Hague, Abedul ;

Naiki, Yoshikazu ;

Hashimoto, Shoji ;

Komatsu, Takayuki ;

Yoshida, Tomoaki ;

Yokochi, Takashi .

CELLULAR IMMUNOLOGY, 2011, 270 (01) :19-24

[2] Nitric oxide and angiogenesis [J].

Cooke, JP ;

Losordo, DW .

CIRCULATION, 2002, 105 (18) :2133-2135

[3] Mercury and human genotoxicity: Critical considerations and possible molecular mechanisms [J].

Crespo-Lopez, Maria Elena ;

Macedo, Gisele L. ;

Pereira, Susana I. D. ;

Arrifano, Gabriela P. F. ;

Picanco-Diniz, Domingos L. W. ;

do Nascimento, Jose Luiz M. ;

Herculano, Anderson M. .

PHARMACOLOGICAL RESEARCH, 2009, 60 (04) :212-220

[4] THALIDOMIDE IS AN INHIBITOR OF ANGIOGENESIS [J].

DAMATO, RJ ;

LOUGHNAN, MS ;

FLYNN, E ;

FOLKMAN, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :4082-4085

[5] Suppression of apoptosis by nitric oxide via inhibition of interleukin-1 beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases [J].

Dimmeler, S ;

Haendeler, J ;

Nehls, M ;

Zeiher, AM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (04) :601-607

[6] SNAP, a NO donor, induces cellular protection only when cortical neurons are submitted to some aggression process [J].

Figueroa, S ;

López, E ;

Arce, C ;

Oset-Gasque, MJ ;

González, MP .

BRAIN RESEARCH, 2005, 1034 (1-2) :25-33

[7]

Further S. J., 1965, LEPROSY REV, V36, P183

[8] Long-lived Drosophila with overexpressed dFOXO in adult fat body [J].

Giannakou, ME ;

Goss, M ;

Jünger, MA ;

Hafen, E ;

Leevers, SJ ;

Partridge, L .

SCIENCE, 2004, 305 (5682) :361-361

[9] Thalidomide and its derivatives: emerging from the wilderness [J].

Gordon, JN ;

Goggin, PM .

POSTGRADUATE MEDICAL JOURNAL, 2003, 79 (929) :127-132

[10] A SERIES OF NORMAL STAGES IN THE DEVELOPMENT OF THE CHICK EMBRYO [J].

HAMBURGER, V ;

HAMILTON, HL .

JOURNAL OF MORPHOLOGY, 1951, 88 (01) :49-&

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