Vectorizing agrochemicals: enhancing bioavailability via carrier-mediated transport

被引:36
作者
Wu, Hanxiang [1 ,2 ]
Xu, Hanhong [1 ,2 ]
Marivingt-Mounir, Cecile [3 ]
Bonnemain, Jean-Louis [4 ]
Chollet, Jean-Francois [3 ]
机构
[1] South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Minist Educ, Guangzhou, Guangdong, Peoples R China
[2] South China Agr Univ, Key Lab Nat Pesticide & Chem Biol, Minist Educ, Guangzhou, Guangdong, Peoples R China
[3] Univ Poitiers, IC2MP, Unite Mixte Rech CNRS 7285, 4 Rue Michel Brunet, F-86073 Poitiers 9, France
[4] Univ Poitiers, Lab Ecol & Biol Interact, Unite Mixte Rech CNRS 7267, Poitiers 9, France
关键词
agrochemical vectorization; propesticide; carrier-mediated transport; phloem transport; systemicity; plant transporters; SYSTEMIC ACQUIRED-RESISTANCE; AMINO-ACID TRANSPORTERS; PHLOEM MOBILITY; SALICYLIC-ACID; RICINUS-COMMUNIS; PARAQUAT TOLERANCE; XENOBIOTICS; FIPRONIL; TRANSLOCATION; DERIVATIVES;
D O I
10.1002/ps.5298
中图分类号
S3 [农学(农艺学)];
学科分类号
0901 ;
摘要
Systemicity of agrochemicals is an advantageous property for controlling phloem sucking insects, as well as pathogens and pests not accessible to contact products. After the penetration of the cuticle, the plasma membrane constitutes the main barrier to the entry of an agrochemical into the sap flow. The current strategy for developing systemic agrochemicals is to optimize the physicochemical properties of the molecules so that they can cross the plasma membrane by simple diffusion or ion trapping mechanisms. The main problem with current systemic compounds is that they move everywhere within the plant, and this non-controlled mobility results in the contamination of the plant parts consumed by vertebrates and pollinators. To achieve the site-targeted distribution of agrochemicals, a carrier-mediated propesticide strategy is proposed in this review. After conjugating a non-systemic agrochemical with a nutrient (alpha-amino acids or sugars), the resulting conjugate may be actively transported across the plasma membrane by nutrient-specific carriers. By applying this strategy, non-systemic active ingredients are expected to be delivered into the target organs of young plants, thus avoiding or minimizing subsequent undesirable redistribution. The development of this innovative strategy presents many challenges, but opens up a wide range of exciting possibilities. (c) 2018 Society of Chemical Industry
引用
收藏
页码:1507 / 1516
页数:10
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