PubChem BioAssay: 2014 update

被引：200

作者：

Wang, Yanli ^{[1
]}

Suzek, Tugba ^{[1
]}

Zhang, Jian ^{[1
]}

Wang, Jiyao ^{[1
]}

He, Siqian ^{[1
]}

Cheng, Tiejun ^{[1
]}

Shoemaker, Benjamin A. ^{[1
]}

Gindulyte, Asta ^{[1
]}

Bryant, Stephen H. ^{[1
]}

机构：

[1] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

关键词：

RNA INTERFERENCE SCREEN; REGULATORS; GENES;

D O I：

10.1093/nar/gkt978

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PubChem's BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for archiving biological tests of small molecules generated through high-throughput screening experiments, medicinal chemistry studies, chemical biology research and drug discovery programs. In addition, the BioAssay database contains data from high-throughput RNA interference screening aimed at identifying critical genes responsible for a biological process or disease condition. The mission of PubChem is to serve the community by providing free and easy access to all deposited data. To this end, PubChem BioAssay is integrated into the National Center for Biotechnology Information retrieval system, making them searchable by Entrez queries and cross-linked to other biomedical information archived at National Center for Biotechnology Information. Moreover, PubChem BioAssay provides web-based and programmatic tools allowing users to search, access and analyze bioassay test results and metadata. In this work, we provide an update for the PubChem BioAssay resource, such as information content growth, new developments supporting data integration and search, and the recently deployed PubChem Upload to streamline chemical structure and bioassay submissions.

引用

页码：D1075 / D1082

页数：8

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