In-vitro characterization of antibacterial bioactive glass containing ceria

被引：109
作者：
Goh, Yi-Fan [1 ]
Alshemary, Ammar Z. [1 ]
Akram, Muhammad [1 ]
Kadir, Mohammed Rafiq Abdul [2 ]
Hussain, Rafaqat [3 ]
机构：
[1] Univ Teknol Malaysia, Fac Sci, Dept Chem, Utm Skudai 81310, Johor Darul Taz, Malaysia
[2] Univ Teknol Malaysia, Fac Biomed Engn & Hlth Sci, Med Implant Technol Grp, Utm Johor Bahru 81310, Malaysia
[3] Univ Teknol Malaysia, IbnuSina Inst Fundamental Sci Studies, Utm Johor Bahru 81310, Johor Darul Taz, Malaysia
来源：
CERAMICS INTERNATIONAL | 2014年 / 40卷 / 01期
关键词：
Electron microscopy; Rare earth biomaterials; Sol-gel growth; Nanostructures; Antibacterial properties; ESCHERICHIA-COLI; SOL-GEL; CEO2; NANOPARTICLES; OPTICAL-PROPERTIES; APATITE FORMATION; AEROBIC-BACTERIA; SURFACE; CELL; MECHANISM; PHOSPHATE;
D O I：
10.1016/j.ceramint.2013.06.062
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Several compositions of bioactive glass (BG) containing ceria were synthesized from chloride precursor using quick alkali sol gel method. XRD data revealed the presence of ceria in 5 and 10 mol% Ce samples. SEM and EDX characterization confirmed the nano-size and elemental composition of all samples, while FTIR data indicated that high Ce content has disrupted the silicate network of BG. UV absorption spectrum showed that ceria in BG samples is present in +3 and +4 oxidation states, depending on the initial cerium content Nitrogen adsorption desorption isotherm confirmed the mesoporosity of the samples. 5 and 10 mol% Ce samples exhibited significant antibacterial properties compared to 1Ce and 50Si samples. All samples induced the formation of apatite particles with Ca/P ratio close to 1.67 upon immersion in simulated body fluid (SBF), confirming their good bioactivity. For the first time, this study has demonstrated that cerium is a promising candidate to impart BG with excellent antibacterial properties without compromising its bioactivity. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
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页码：729 / 737
页数：9
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