Silver-Mediated Trifluoromethylation of Aryldiazonium Salts: Conversion of Amino Group into Trifluoromethyl Group

被引：219

作者：

Wang, Xi ^{[1
]}

Xu, Yan ^{[1
]}

Mo, Fanyang ^{[1
]}

Ji, Guojing ^{[1
]}

Qiu, Di ^{[1
]}

Feng, Jiajie ^{[1
]}

Ye, Yuxuan ^{[1
]}

Zhang, Songnan ^{[1
]}

Zhang, Yan ^{[1
]}

Wang, Jianbo ^{[1
]}

机构：

[1] Peking Univ, BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 28期

关键词：

PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; BORONIC ACIDS; CATALYZED TRIFLUOROMETHYLATION; ARYLBORONIC ACIDS; SYNTHETIC METHODS; DIAZONIUM SALTS; ALKYL NITRITES; ARYL STANNANES; ARENES; FLUORINATION;

D O I：

10.1021/ja4056239

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel strategy for aromatic trifluoromethylation by converting aromatic amino group into CF3 group is reported herein. This method, which can be considered as trifluoromethylation variation of the classic Sandmeyer reaction, uses readily available aromatic amines as starting materials and is performed under mild conditions.

引用

收藏

页码：10330 / 10333

页数：4

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