High-dose, variable-length, intravenous N-acetylcysteine (HINAC) therapy for acetaminophen poisoning

被引：0
作者：
Moore, Philip W. [3 ]
Donovan, J. Ward [3 ]
Burkhart, Keith K. [1 ]
Daniello, Todd C. [2 ]
Smith, Erin Mancuso [4 ]
Andharia, Neel [3 ]
Dorai, Suprina [5 ]
Eygnor, Jessica [5 ]
Wirt, Yijin [3 ]
机构：
[1] US FDA, Rockville, MD 20857 USA
[2] Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
[3] PinnacleHlth Syst, Harrisburg, PA USA
[4] Novant Hlth Presbyterian Med Ctr, Charlotte, NC USA
[5] Lehigh Valley Hlth Network, Lehigh Valley, PA USA
来源：
CLINICAL TOXICOLOGY | 2013年 / 51卷 / 07期
关键词：
Acetaminophen (paracetamol); N-acetylcysteine; Hepatotoxicity;
D O I：
暂无
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
14
引用
收藏
页码：581 / 581
页数：1
相关论文
共 50 条
  • [21] ACETAMINOPHEN OVERDOSE - A 48-HOUR INTRAVENOUS N-ACETYLCYSTEINE TREATMENT PROTOCOL
    SMILKSTEIN, MJ
    BRONSTEIN, AC
    LINDEN, C
    AUGENSTEIN, WL
    KULIG, KW
    RUMACK, BH
    ANNALS OF EMERGENCY MEDICINE, 1991, 20 (10) : 1058 - 1063
  • [22] A Gargantuan Acetaminophen Level in an Acidemic Patient Treated Solely With Intravenous N-Acetylcysteine
    Zell-Kanter, Michele
    Coleman, Patrick
    Whiteley, Patrick M.
    Leikin, Jerrold B.
    AMERICAN JOURNAL OF THERAPEUTICS, 2013, 20 (01) : 104 - 106
  • [23] Assessment of high-dose acetylcysteine in acute high-risk paracetamol (acetaminophen) ingestion
    Moss, Michael J.
    Hinchman, Brynne
    Lambson, Joseph E.
    Scott, Julie W.
    Hinckley, Paul
    Wylie, Sawyer J.
    Dorey, Alyrene
    CLINICAL TOXICOLOGY, 2024, 62 (08) : 519 - 525
  • [24] High-Dose N-Acetylcysteine in the Prevention of COPD Exacerbations: Rationale and Design of the PANTHEON Study
    Zheng, Jin-Ping
    Wen, Fu-Qiang
    Bai, Chun-Xue
    Wan, Huan-Ying
    Kang, Jian
    Chen, Ping
    Yao, Wan-Zhen
    Ma, Li-Jun
    Xia, Qi-kui
    Gao, Yi
    Zhong, Nan-Shan
    COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2013, 10 (02) : 164 - 171
  • [25] A retrospective evaluation of shortened-duration oral N-acetylcysteine for the treatment of acetaminophen poisoning
    Betten D.P.
    Burner E.E.
    Thomas S.C.
    Tomaszewski C.
    Clark R.F.
    Journal of Medical Toxicology, 2009, 5 (4) : 183 - 190
  • [26] High-dose N-acetylcysteine decreases silica-induced lung fibrosis in the rat
    Zhang, Hua
    Yin, Gang
    Jiang, Hao
    Zhang, Chunling
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2013, 41 (04) : 1179 - 1186
  • [27] Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose
    Duffull, S. B.
    Isbister, G. K.
    CLINICAL TOXICOLOGY, 2013, 51 (08) : 772 - 776
  • [28] Oral n-acetylcysteine therapy for infant acetaminophen exposures: a case series
    Kolbeck, Matthew
    Wiener, Brian
    Howland, Mary Ann
    Su, Mark
    Marraffa, Jeanna
    Calleo, Vincent
    CLINICAL TOXICOLOGY, 2024, 62 : 131 - 131
  • [29] A PHASE II STUDY ON SAFETY AND EFFICACY OF HIGH-DOSE N-ACETYLCYSTEINE IN PATIENTS WITH CYSTIC FIBROSIS
    Dauletbaev, N.
    Fischer, P.
    Aulbach, B.
    Gross, J.
    Kusche, W.
    Thyroff-Friesinger, U.
    Wagner, T. O. F.
    Bargon, J.
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2009, 14 (08) : 352 - 358
  • [30] Should high-dose N-acetylcysteine be given in cases of massive paracetamol overdoses: A narrative review
    Erichsen, Philip Ahle
    Dalhoff, Kim
    Andersen, Michael Asger
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2024, 135 (03) : 285 - 294
12345