A Fluorescent Guanosine Dinucleoside as a Selective Switch-On Sensor for c-myc G-Quadruplex DNA with Potent Anticancer Activities

被引：23

作者：

Kumar, Y. Pavan ^{[1
]}

Bhowmik, Sudipta ^{[1
]}

Das, Rabindra Nath ^{[2
]}

Bessi, Irene ^{[3
,4
]}

Paladhi, Sushovan ^{[1
]}

Ghosh, Rita ^{[5
]}

Schwalbe, Harald ^{[3
,4
]}

Dash, Jyotirmayee ^{[1
,2
]}

机构：

[1] Indian Assoc Cultivat Sci Jadavpur, Dept Organ Chem, Kolkata 700032, India

[2] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741252, W Bengal, India

[3] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60438 Frankfurt, Germany

[4] Ctr Biomol Magnet Resonance, D-60438 Frankfurt, Germany

[5] Univ Kalyani, Dept Biochem & Biophys, Kalyani 741235, W Bengal, India

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 35期

关键词：

cell cycles; click chemistry; fluorescence; nucleosides; G-quadruplex DNA; G-QUARTETS; PROBES; LOGIC; CHEMISTRY; APOPTOSIS; DYES; RNA;

D O I：

10.1002/chem.201302107

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Like likes like! A novel fluorescent C2-symmetric guanosine-based dinucleoside has been engineered by chemical ligation of two guanosine units with a biocompatible dansyl tag. The nucleoside exhibits high selectivity for c-myc G-quadruplex DNA through fluorescence enhancement over duplex DNA and other promoter G-quadruplexes (see scheme). It stains the nucleus preferentially, arrests the cell cycle at the G2/M phase, inhibits cell growth, and induces apoptosis in A375 cancer cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11502 / 11506

页数：5

共 43 条

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