A Fluorescent Guanosine Dinucleoside as a Selective Switch-On Sensor for c-myc G-Quadruplex DNA with Potent Anticancer Activities

被引：23
|
作者：
Kumar, Y. Pavan [1 ]
Bhowmik, Sudipta [1 ]
Das, Rabindra Nath [2 ]
Bessi, Irene [3 ,4 ]
Paladhi, Sushovan [1 ]
Ghosh, Rita [5 ]
Schwalbe, Harald [3 ,4 ]
Dash, Jyotirmayee [1 ,2 ]
机构：
[1] Indian Assoc Cultivat Sci Jadavpur, Dept Organ Chem, Kolkata 700032, India
[2] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741252, W Bengal, India
[3] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60438 Frankfurt, Germany
[4] Ctr Biomol Magnet Resonance, D-60438 Frankfurt, Germany
[5] Univ Kalyani, Dept Biochem & Biophys, Kalyani 741235, W Bengal, India
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 35期
关键词：
cell cycles; click chemistry; fluorescence; nucleosides; G-quadruplex DNA; G-QUARTETS; PROBES; LOGIC; CHEMISTRY; APOPTOSIS; DYES; RNA;
D O I：
10.1002/chem.201302107
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Like likes like! A novel fluorescent C2-symmetric guanosine-based dinucleoside has been engineered by chemical ligation of two guanosine units with a biocompatible dansyl tag. The nucleoside exhibits high selectivity for c-myc G-quadruplex DNA through fluorescence enhancement over duplex DNA and other promoter G-quadruplexes (see scheme). It stains the nucleus preferentially, arrests the cell cycle at the G2/M phase, inhibits cell growth, and induces apoptosis in A375 cancer cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11502 / 11506
页数：5
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