Anti-inflammatory and anti-nociceptive activity of disodium glycyrrhetinic acid hemiphthalate

被引：23
|
作者：
Khaksa, G
Zolfaghari, ME
Dehpour, AR
Samadian, T
机构：
[1] Pharmaceutical Res. Ctr. Darou P., Tehran
来源：
PLANTA MEDICA | 1996年 / 62卷 / 04期
关键词：
non-steroidal anti-inflammatory agents; antinociceptive; carrageenin; glycyrrhetinic acid derivatives;
D O I：
10.1055/s-2006-957894
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The anti-inflammatory and anti-nociceptive effects of disodium glycyrrhetinic acid hemiphthalate (glycyrrhetinic acid 3 beta-O-hemiphthalate sodium) after parenteral administration were determined in several animal models. Disodium glycyrrhetinic acid hemiphthalate (GAP) significantly inhibited the rat paw edema induced by carrageenin (ID50 = 21.37 mg/kg), and mice writhing responses caused by acetic acid (ID50 = 9.12 mg/kg). The potency of disodium glycyrrhetinic acid hemiphthalate was about 13.05 times higher than acetylsalicylic acid in inhibiting rat paw edema and 12.84 times higher in inhibiting abdominal constrictions in mice.
引用
收藏
页码：326 / 328
页数：3
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