Tolypodiol, an antiinflammatory diterpenoid from the cyanobacterium Tolypothrix nodosa

被引：31
作者：
Prinsep, MR
Thomson, RA
West, ML
Wylie, BL
机构：
[1] UNIV QUEENSLAND,CTR DRUG DESIGN & DEV,BRISBANE,QLD 4072,AUSTRALIA
[2] UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,SANTA BARBARA,CA 93106
来源：
JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 08期
关键词：
D O I：
10.1021/np9602574
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new diterpenoid, tolypodiol (1), has been isolated from the terrestrial cyanobacterium Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The monoacetate derivative 2 was prepared. Tolypodiol(1) and its monoacetate derivative 2 show potent antiinflammatory activity in the mouse ear edema assay.
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页码：786 / 788
页数：3
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