Development and function of CD25+CD4+ regulatory T cells

被引：190

作者：

Fehérvari, Z ^{[1
]}

Sakaguchi, S ^{[1
]}

机构：

[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, Kyoto 6068507, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 02期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/j.coi.2004.01.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The essential role played by CD25(+)CD4(+) regulatory T cells (T-R cells) in the control of physiological as well as pathological immunity is now well established, but many aspects of their biology still remain unclear. One of the unresolved issues regards their development: where does this occur, what signals are required, and how do T-R cells fit into the larger taxonomy of the T-cell family? Recent data has begun to shed light on the development and function of these important cells.

引用

页码：203 / 208

页数：6

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