Demethoxycurcumin and its Semisynthetic Analogues as Antitubercular Agents

被引：23

作者：

Agrawal, Dinesh Kumar ^{[1
]}

Saikia, Dharmendra ^{[2
]}

Tivvari, Richa ^{[2
]}

Ojha, Shweta ^{[2
]}

Shanker, Karuna ^{[1
]}

Kumar, Jonnala Kotesh ^{[1
]}

Gupta, Anil Kumar ^{[2
]}

Tandon, Sudeep ^{[3
]}

Negi, Arvind Singh ^{[1
]}

Khanuja, Suman Preet Singh ^{[2
]}

机构：

[1] CSIR, Cent Inst Med & Aromat Plants, Div Analyt Chem, Lucknow 226015, Uttar Pradesh, India

[2] CSIR, Cent Inst Med & Aromat Plants, Genet Resources & Biotechnol Div, Lucknow 226015, Uttar Pradesh, India

[3] CSIR, Cent Inst Med & Aromat Plants, Proc Div, Lucknow 226015, Uttar Pradesh, India

来源：

PLANTA MEDICA | 2008年 / 74卷 / 15期

关键词：

Curcuma longa; Zingiberaceae; Mycobacterium tuberculosis; demethoxycurcumin; phenolic derivatives; antitubercular activity;

D O I：

10.1055/s-0028-1088335

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H37RV strain at 200 mu g/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 mu g/mL.

引用

页码：1828 / 1831

页数：4

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