S-bridged complex of 99mTc with fac(S)-[Rh(aet)3]: Quality control, characterization and biodistribution studies in rats

被引：7

作者：

Amir, N. ^{[1
]}

Roohi, S. ^{[1
]}

Pervez, S. ^{[1
]}

Mushtaq, A. ^{[1
]}

Jehangir, M. ^{[1
]}

Miyashita, Y. ^{[2
]}

Okamoto, K. ^{[2
]}

机构：

[1] Pakistan Inst Nucl Sci & Technol, Isotope Prod Div, Islamabad, Pakistan

[2] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 3058571, Japan

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2009年 / 279卷 / 01期

关键词：

PERFUSION IMAGING AGENTS; ELECTROCHEMICAL PROPERTIES; TRINUCLEAR COMPLEXES; CRYSTAL-STRUCTURES; BRAIN; TECHNETIUM(V); LIGAND;

D O I：

10.1007/s10967-007-7244-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

fac(S)-[Rh(aet)(3)] (aet = 2-aminoethanethiolate) is N3S3 metalloligand which can coordinate to transition metal ions to form S-bridge polynuclear complexes. The reaction was carried out between (TcO4Na)-Tc-99m and fac(S)-[Rh(aet)(3)] in the presence of SnCl2 center dot 2H(2)O. A complex analogous to [Re{Rh(aet(3))}(2)](3+) is formed.(6) A simple method for radiolabeling of fac(S)-[Rh(aet)(3)] with Tc-99m has been developed and radiolabeling efficiency was higher than 99%. Effect of SnCl2 center dot 2H(2)O concentration, electrophoresis, HPLC, UV-Visible absorption spectra and biodistribution studies in rats were performed. Higher uptake by kidneys showed rapid distributions of the labeled fac(S)-[Rh(aet)(3)]. Liver uptake was significant, stomach, lungs and intestine uptake was high at 4 hours post injection time.

引用

页码：25 / 30

页数：6

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