Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta)

被引：99

作者：

Mao, Wenjun ^{[1
]}

Li, Hongyan ^{[1
]}

Li, Yi ^{[2
]}

Zhang, Huijuan ^{[1
]}

Qi, Xiaohui ^{[1
]}

Sun, Haihong ^{[1
]}

Chen, Yin ^{[1
]}

Guo, Shoudong ^{[1
]}

机构：

[1] Ocean Univ China, Inst Marine Drug & Food, Qingdao 266003, Peoples R China

[2] PLA 401 Hosp, Qingdao 266071, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2009年 / 44卷 / 01期

关键词：

Sulfated polysaccharide; Chemical characteristic; Anticoagulant activity; MARINE GREEN-ALGA; NMR ANALYSIS; NITIDUM; ULVAN;

D O I：

10.1016/j.ijbiomac.2008.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A polysaccharide was isolated from marine green algae Monostroma latissimum, and its chemical characteristic and anticoagulant activity were investigated. The results demonstrated that the polysaccharide was high rhamnose-containing sulfated polysaccharide, and was mainly composed of 1,2-linked L-rhamnose residues with sulfate groups substituted at positions C-3 and/or C-4. The sulfated polysaccharide exhibited high anticoagulant activities by assays of the activated partial thromboplastin time (APTT) and thrombin time (TT). The anticoagulant property of the sulfated polysaccharide was mainly attributed to powerful potentiation thrombin by heparin cofactor II. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：70 / 74

页数：5

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