Tumor necrosis factor alpha -238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes

被引：13

作者：

Dutta, Deep ^{[1
,2
,3
]}

Choudhuri, Subhadip ^{[1
,2
,3
]}

Mondal, Samim Ali ^{[1
,2
,3
]}

Maisnam, Indira ^{[1
,2
,3
]}

Reza, Abu Hena Hasanoor ^{[1
,2
,3
]}

Ghosh, Sujoy ^{[1
,2
,3
]}

Chowdhury, Subhankar ^{[1
,2
,3
]}

Bhattacharya, Basudev ^{[1
,2
,3
]}

Mukhopadhyay, Satinath ^{[1
,2
,3
]}

机构：

[1] IPGMER, Dept Endocrinol & Metab, Kolkata 700020, India

[2] SSKM Hosp, Kolkata 700020, India

[3] IPGMER, Dept Biochem, Dr BC Roy Postgrad Inst Basic Med Educ & Res, Kolkata 700020, India

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2013年 / 99卷 / 03期

关键词：

TNF alpha-238 G -> A polymorphism; TNF alpha-308 G -> A polymorphism; IL6-174 G -> C polymorphism; Prediabetes; Insulin resistance; IMPAIRED GLUCOSE-TOLERANCE; PROMOTER POLYMORPHISM; INSULIN-RESISTANCE; GREATER-THAN; ASSOCIATION; OBESITY; G-308A; TNF; PREVENTION; MELLITUS;

D O I：

10.1016/j.diabres.2012.12.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prediabetes (IPD; n = 122) and normoglycemic individuals (n = 100) underwent assessment of polymorphisms of TNF alpha (-238, -308) and IL6 (-174). After 27.25 +/- 5.64 months, 16 IPD had reverted to normoglycemia and 18 progressed to diabetes. TNF alpha -238AA/GA genotypes were significantly more common in IPD, had higher TNF alpha, higher progression to diabetes and lower reversal. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E37 / E41

页数：5

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