Duodenal gastrointestinal stromal tumors: Review on clinical and surgical aspects

被引:17
作者
Cavallaro, G. [1 ]
Polistena, A. [2 ]
D'Ermo, G. [2 ]
Pedulla, G. [2 ]
De Toma, G. [2 ]
机构
[1] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Rome, Italy
[2] Univ Roma La Sapienza, Dept Surg P Valdoni, Rome, Italy
关键词
Duodenal tumors; GIST; FINE-NEEDLE-ASPIRATION; TERM-FOLLOW-UP; IMATINIB MESYLATE; MANAGEMENT; DIAGNOSIS; RESECTION;
D O I
10.1016/j.ijsu.2012.08.015
中图分类号
R61 [外科手术学];
学科分类号
摘要
Introduction: Gastrointestinal stromal tumors (GISTs) arising in the duodenum represent a rare entity and can be very demanding to manage. The diagnosis can be difficult (as these tumors can be misdiagnosed as pancreatic head tumors), and to treat owing to the complex anatomy of the duodenum and of the pancreatic head. Complete resection may require extensive procedures such as pancreaticodudodenectomy. Methods and results: An extensive literature review regarding clinico-pathological features, diagnostic investigations and surgical options in the management of duodenal GISTs has been performed. Conclusions: Duodenal GISTs have uncertain malignant potential, and they may be asymptomatic, or present with abdominal pain or bleeding. A preoperative diagnosis can be difficult to obtain. Endoscopic ultrasound and fine needle aspiration cytology (FNAC) may be helpful. Surgical R0 resection remains the only curative approach. However, owing to the complex anatomy of the duodenum, limited resection is not always feasible. In these cases, extensive procedures such as pancreaticoduodenectomy or pancreas-preserving duodenectomy are the treatment of choice. (C) 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:463 / 465
页数:3
相关论文
共 28 条
[1]  
[Anonymous], INT J COLORECTAL DIS
[2]   Segmental duodenectomy for gastrointestinal stromal tumor of the duodenum [J].
Buchs, Nicolas Christian ;
Bucher, Pascal ;
Gervaz, Pascal ;
Ostermann, Sandrine ;
Pugin, Francois ;
Morel, Philippe .
WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (22) :2788-2792
[3]   c-kit immunocytochemical staining in the cytologic diagnosis of metastatic gastrointestinal stromal tumor -: A report of two cases [J].
Cheuk, W ;
Lee, KC ;
Chan, JKC .
ACTA CYTOLOGICA, 2000, 44 (04) :679-685
[4]   Management and Outcome of Gastrointestinal Stromal Tumors of the Duodenum [J].
Chung, Jun Chul ;
Chu, Chong Woo ;
Cho, Gyu Seok ;
Shin, Eung Jin ;
Lim, Chul Wan ;
Kim, Hyung Chul ;
Song, Ok Pyung .
JOURNAL OF GASTROINTESTINAL SURGERY, 2010, 14 (05) :880-883
[5]   Approval Summary: Imatinib Mesylate in the Adjuvant Treatment of Malignant Gastrointestinal Stromal Tumors [J].
Cohen, Martin H. ;
Cortazar, Patricia ;
Justice, Robert ;
Pazdur, Richard .
ONCOLOGIST, 2010, 15 (03) :300-307
[6]   Gastrointestinal stromal tumours [J].
Connolly, EM ;
Gaffney, E ;
Reynolds, JV .
BRITISH JOURNAL OF SURGERY, 2003, 90 (10) :1178-1186
[7]   Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors [J].
Demetri, GD ;
von Mehren, M ;
Blanke, CD ;
Van den Abbeele, AD ;
Eisenberg, B ;
Roberts, PJ ;
Heinrich, MC ;
Tuveson, DA ;
Singer, S ;
Janicek, M ;
Fletcher, JA ;
Silverman, SG ;
Silberman, SL ;
Capdeville, R ;
Kiese, B ;
Peng, B ;
Dimitrijevic, S ;
Druker, BJ ;
Corless, C ;
Fletcher, CDM ;
Joensuu, H .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (07) :472-480
[8]  
Erickson RA, 1997, ACTA CYTOL, V41, P1647
[9]   Diagnosis of gastrointestinal stromal tumors: A consensus approach [J].
Fletcher, CDM ;
Berman, JJ ;
Corless, C ;
Gorstein, F ;
Lasota, J ;
Longley, BJ ;
Miettinen, M ;
O'Leary, TJ ;
Remotti, H ;
Rubin, BP ;
Shmookler, B ;
Sobin, LH ;
Weiss, SW .
HUMAN PATHOLOGY, 2002, 33 (05) :459-465
[10]  
Fu Kai, 2002, Ann Diagn Pathol, V6, P294