Asymmetric Organocatalysis and Photoredox Catalysis for the -Functionalization of Tetrahydroisoquinolines

被引：30

作者：

Hou, Hong ^{[1
,2
]}

Zhu, Shaoqun ^{[1
]}

Atodiresei, Iuliana ^{[1
]}

Rueping, Magnus ^{[1
,3
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

[2] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225009, Jiangsu, Peoples R China

[3] KAUST, Catalysis Ctr KCC, Thuwal 239556900, Saudi Arabia

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 10期

基金：

欧洲研究理事会;

关键词：

Cyclic ketones; Tetrahydroisoquinolines; Organocatalysis; Photocatalysis; Alkylation; VISIBLE-LIGHT PHOTOCATALYSIS; TERTIARY-AMINES; COMBINING PHOTOREDOX; DUAL CATALYSIS; COUPLING REACTIONS; METAL; KETONES; ACID; TRANSFORMATIONS; METHODOLOGY;

D O I：

10.1002/ejoc.201800117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric -alkylation of tetrahydroisoquinolines with cyclic ketones has been accomplished in the presence of a combined catalytic system consisting of a visible-light photoredox catalyst and a chiral primary amine organocatalyst. The desired products were obtained in good yields, high enantioselectivity, and good to excellent diastereoselectivity. (PC: photoredox cycle, EN: enamine cycle).

引用

页码：1277 / 1280

页数：4

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