Small Bite-Angle P-OP Ligands for Asymmetric Hydroformylation and Hydrogenation

被引：41

作者：

Fernandez-Perez, Hector ^{[1
]}

Benet-Buchholz, J. ^{[1
]}

Vidal-Ferran, Anton ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 14期

关键词：

PHOSPHITE LIGANDS; ENANTIOSELECTIVE HYDROFORMYLATION; RHODIUM COMPLEXES;

D O I：

10.1021/ol401494x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of small bite-angle phosphine-phosphite (P-OP) ligands have been synthesized by a two-step method. The key intermediate was prepared by an unprecedented asymmetric carbonyl reduction of a phosphamide using the CBS (Corey-Bakshi-Shibata) catalyst. The topology of these ligands (a configurationally stable stereogenic carbon with two heteroatom substituents) and their small bite-angle (created by the close proximity of the two ligating groups to the metal center) together provide a rigid asymmetric environment around this center, enabling high stereoselectivity in hydroformylations and hydrogenations of standard substrates.

引用

页码：3634 / 3637

页数：4

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