Non-donor specific anti-human leukocyte antigen (HLA) antibodies are not associated with poor outcome in hematopoietic stem cell transplant recipients

被引：7

作者：

Andolina, J. R. ^{[1
]}

Walia, R. ^{[1
]}

Oliva, J. ^{[2
]}

Baran, A. ^{[2
]}

Liesveld, J. ^{[2
]}

Becker, M. W. ^{[2
]}

Busacco, A. ^{[3
]}

Coppage, M. ^{[3
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Pediat, Golisano Childrens Hosp, Rochester, NY 14642 USA

[2] Univ Rochester, Med Ctr, Dept Med, Wilmot Canc Ctr, Rochester, NY 14642 USA

[3] Univ Rochester, Med Ctr, Dept Pathol, Rochester, NY 14642 USA

来源：

HUMAN IMMUNOLOGY | 2020年 / 81卷 / 08期

关键词：

anti-HLA antibodies; Hematopoietic stem cell transplant; GRAFT FAILURE; IMPACT; DONOR; TRANSFUSION; SURVIVAL; ENGRAFTMENT; PREGNANCY; HISTORY; RISK;

D O I：

10.1016/j.humimm.2020.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Testing for anti-human leukocyte antigen (HLA) antibodies has now become standard practice in allogeneic hematopoietic stem cell transplantation (HSCT), and anti-HLA antibodies (both donor specific and non-donor specific) are being identified and have many potential consequences. Most studies suggest that donor-specific HLA antibodies lead to adverse outcomes, though little is reported on non-donor specific anti-HLA antibodies. We present the results of a retrospective cohort analysis of 157 patients who received HSCT at the University of Rochester over a period of four years. We identified 45 patients (28.7%) who had detectable anti-HLA antibodies, while only one patient (0.6%) had donor-specific anti-HLA antibodies. Patients with prior pregnancies and multiple transfusions were at increased risk to develop antibodies. In our cohort, the presence of non-donor specific anti-HLA antibodies did not significantly impact overall survival, progression free survival, graft failure, or transplant-related mortality.

引用

页码：407 / 412

页数：6

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