Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes

被引：11
作者：
de Jongste, Adriaan H. C. [1 ,2 ]
de Graaf, Marieke T. [2 ]
van den Broek, Patricia D. M. [1 ]
Kraan, Jaco [1 ]
Smitt, Peter A. E. Sillevis [2 ]
Gratama, Jan W. [1 ]
机构：
[1] Erasmus Univ, Med Ctr, Dr Daniel Den Hoed Canc Ctr, Dept Med Oncol, NL-3075 EA Rotterdam, Netherlands
[2] Erasmus Univ, Med Ctr, Dept Neurol, NL-3015 CE Rotterdam, Netherlands
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 258卷 / 1-2期
关键词：
Paraneoplastic neurological syndromes; Hu-antibody; Cerebrospinal fluid; Regulatory T cells; Central memory T cells; B cells; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; DENDRITIC CELLS; NO EVIDENCE; EXPRESSION; ENCEPHALOMYELITIS; CNS; IMBALANCES; DISORDERS; PEPTIDES;
D O I：
10.1016/j.jneuroim.2013.02.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：85 / 90
页数：6
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