Apicomplexan plastids as drug targets

被引：187

作者：

McFadden, GI ^{[1
]}

Roos, DS

机构：

[1] Univ Melbourne, Sch Bot, Plant Cell Biol Res Ctr, Parkville, Vic 3052, Australia

[2] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 08期

基金：

澳大利亚研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0966-842X(99)01547-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prokaryotic metabolic pathways in the relict plastid of apicomplexan parasites make this organelle a promising target for drug development. The parasiticidal activity of several herbicides and antibacterial antibiotics is suspected to be a result of their ability to inhibit key plastid activities.

引用

页码：328 / 333

页数：6

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