Transmission of Ebola virus from pigs to non-human primates

被引：132

作者：

Weingartl, Hana M. ^{[1
,2
]}

Embury-Hyatt, Carissa ^{[1
]}

Nfon, Charles ^{[1
]}

Leung, Anders ^{[3
]}

Smith, Greg ^{[1
]}

Kobinger, Gary ^{[2
,3
]}

机构：

[1] Canadian Food Inspect Agcy, Natl Ctr Foreign Anim Dis, Winnipeg, MB R3E 3M4, Canada

[2] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[3] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada

来源：

SCIENTIFIC REPORTS | 2012年 / 2卷

关键词：

HEMORRHAGIC-FEVER; RHESUS-MONKEYS; INFECTION; CHALLENGE;

D O I：

10.1038/srep00811

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ebola viruses (EBOV) cause often fatal hemorrhagic fever in several species of simian primates including human. While fruit bats are considered natural reservoir, involvement of other species in EBOV transmission is unclear. In 2009, Reston-EBOV was the first EBOV detected in swine with indicated transmission to humans. In-contact transmission of Zaire-EBOV (ZEBOV) between pigs was demonstrated experimentally. Here we show ZEBOV transmission from pigs to cynomolgus macaques without direct contact. Interestingly, transmission between macaques in similar housing conditions was never observed. Piglets inoculated oro-nasally with ZEBOV were transferred to the room housing macaques in an open inaccessible cage system. All macaques became infected. Infectious virus was detected in oro-nasal swabs of piglets, and in blood, swabs, and tissues of macaques. This is the first report of experimental interspecies virus transmission, with the macaques also used as a human surrogate. Our finding may influence prevention and control measures during EBOV outbreaks.

引用

页数：4

共 17 条

[1] Discovery of Swine as a Host for the Reston ebolavirus [J].

Barrette, Roger W. ;

Metwally, Samia A. ;

Rowland, Jessica M. ;

Xu, Lizhe ;

Zaki, Sherif R. ;

Nichol, Stuart T. ;

Rollin, Pierre E. ;

Towner, Jonathan S. ;

Shieh, Wun-Ju ;

Batten, Brigid ;

Sealy, Tara K. ;

Carrillo, Consuelo ;

Moran, Karen E. ;

Bracht, Alexa J. ;

Mayr, Gregory A. ;

Sirios-Cruz, Magdalena ;

Catbagan, Davinio P. ;

Lautner, Elizabeth A. ;

Ksiazek, Thomas G. ;

White, William R. ;

McIntosh, Michael T. .

SCIENCE, 2009, 325 (5937) :204-206

[2] PATHOLOGY OF EXPERIMENTAL EBOLA VIRUS-INFECTION IN MONKEYS [J].

BASKERVILLE, A ;

BOWEN, ETW ;

PLATT, GS ;

MCARDELL, LB ;

SIMPSON, DIH .

JOURNAL OF PATHOLOGY, 1978, 125 (03) :131-&

[3]

DALGARD DW, 1992, LAB ANIM SCI, V42, P152

[4] Predicting the spread of foot and mouth disease by airborne virus [J].

Donaldson, AI ;

Alexandersen, S .

REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES, 2002, 21 (03) :569-575

[5] Ebola haemorrhagic fever [J].

Feldmann, Heinz ;

Geisbert, Thomas W. .

LANCET, 2011, 377 (9768) :849-862

[6] Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study [J].

Geisbert, Thomas W. ;

Lee, Amy C. H. ;

Robbins, Marjorie ;

Geisbert, Joan B. ;

Honko, Anna N. ;

Sood, Vandana ;

Johnson, Joshua C. ;

de Jong, Susan ;

Tavakoli, Iran ;

Judge, Adam ;

Hensley, Lisa E. ;

MacLachlan, Ian .

LANCET, 2010, 375 (9729) :1896-1905

[7] Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses [J].

Geisbert, Thomas W. ;

Daddario-DiCaprio, Kathleen M. ;

Geisbert, Joan B. ;

Reed, Douglas S. ;

Feldmann, Friederike ;

Grolla, Allen ;

Stroeher, Ute ;

Fritz, Elizabeth A. ;

Hensley, Lisa E. ;

Jones, Steven M. ;

Feldmann, Heinz .

VACCINE, 2008, 26 (52) :6894-6900

[8] Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory [J].

Jaax, N ;

Jahrling, P ;

Geisbert, T ;

Geisbert, J ;

Steele, K ;

McKee, K ;

Nagley, D ;

Johnson, E ;

Jaax, G ;

Peters, C .

LANCET, 1995, 346 (8991-2) :1669-1671

[9]

Jaax NK, 1996, ARCH PATHOL LAB MED, V120, P140

[10]

Jahrling PB, 1996, ARCH VIROL, P115

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