Near infrared fluorescent optical imaging for nodal staging

被引:41
作者
Sampath, Lakshmi [1 ,2 ]
Wang, Wei
Sevick-Muraca, Eva M. [1 ,2 ]
机构
[1] Baylor Coll Med, Div Mol Imaging, Dept Radiol, Houston, TX 77030 USA
[2] Baylor Breast Ctr, Houston, TX 77030 USA
关键词
fluorescence imaging; breast cancer; human epidermal growth factor receptor-2; (HER2); lymph node staging; intradermal administration;
D O I
10.1117/1.2953498
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Current techniques to assess lymph node metastases in cancer patients include lymphoscintigraphy after administration of a nonspecific radiocolloid in order to locate and resect lymph nodes for pathological examination of harbored cancer cells. Clinical trials involving intradermal or subcutaneous injection of antibody-based nuclear imaging agents have demonstrated the feasibility for target-specific, molecular imaging of cancer-positive lymph nodes. The basis for employing near-infrared (NIR) optical imaging for assessing disease is evidenced by recent work showing functional lymph imaging in mice, swine, and humans. We review antibody-based immunolym-phoscintigraphy with an emphasis on the use of trastuzumab (or Herceptin) to target human epidermal growth factor receptor-2 (HER2) overexpressed in some breast cancers. Specifically, we review in vitro and preclinical imaging data from our laboratory that show how the dual-labeled agent (In-111-DTPA)(n)-trastuzumab-(IRDye800)(m) utilizes the high photon count provided by an NIR fluorescent dye, IRDye 800CW, and the radioactive signal from a gamma emitter, Indium-111, for possible detection of HER2 metastasis in lymph nodes. We show that the accumulation and clearance of (In-111-DTPA)(n)-trastuzumab-IRDye800)(m) from the axillary nodes of mice occurs 48 h after intradermal injection into the dorsal aspect of the foot. The requirement for long clearance times from normal, cancer-negative nodes presents challenges for nuclear imaging agents with limited half-lives but does not hamper NIR optical imaging. (C) 2008 Society of Photo-Optical Instrumentation Engineers.
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页数:10
相关论文
共 56 条
[1]   CLINICAL-EXPERIENCE WITH INTRA LYMPHATIC ADMINISTRATION OF IN-111 LABELED MONOCLONAL-ANTIBODY PAY-276 FOR THE DETECTION OF PELVIC NODAL METASTASES IN PROSTATIC-CARCINOMA [J].
ABDELNABI, HH ;
ORTMANNABI, JA ;
SEE, W ;
LEE, J ;
IRETON, R ;
BOILEAU, M ;
UNGER, MW ;
HALVERSON, C .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1990, 16 (03) :149-156
[2]   MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles [J].
Artemov, D ;
Mori, N ;
Okollie, B ;
Bhujwalla, ZM .
MAGNETIC RESONANCE IN MEDICINE, 2003, 49 (03) :403-408
[3]  
Behr TM, 2001, NEW ENGL J MED, V345, P995
[4]   Labeling anti-HER2/neu monoclonal antibodies with 111In and 90Y using a bifunctional DTPA chelating agent [J].
Blend, MJ ;
Stastny, JJ ;
Swanson, SM ;
Brechbiel, MW .
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2003, 18 (03) :355-363
[5]   HUMANIZATION OF AN ANTI-P185HER2 ANTIBODY FOR HUMAN CANCER-THERAPY [J].
CARTER, P ;
PRESTA, L ;
GORMAN, CM ;
RIDGWAY, JBB ;
HENNER, D ;
WONG, WLT ;
ROWLAND, AM ;
KOTTS, C ;
CARVER, ME ;
SHEPARD, HM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4285-4289
[6]   Bioconjugated gold nanoparticles as a molecular based contrast agent: Implications for imaging of deep tumors using optoacoustic tomography [J].
Copland, JA ;
Eghtedari, M ;
Popov, VL ;
Kotov, N ;
Mamedova, N ;
Motamedi, M ;
Oraevsky, AA .
MOLECULAR IMAGING AND BIOLOGY, 2004, 6 (05) :341-349
[7]   Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans [J].
Corlu, Alper ;
Choe, Regine ;
Durduran, Turgut ;
Rosen, Mark A. ;
Schweiger, Martin ;
Arridge, Simon R. ;
Schnall, Mitchell D. ;
Yodh, Arjun G. .
OPTICS EXPRESS, 2007, 15 (11) :6696-6716
[8]  
DELAND FH, 1980, CANCER RES, V40, P2997
[9]   Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent [J].
Dennis, Mark S. ;
Jin, Hongkui ;
Dugger, Debra ;
Yang, Renhui ;
McFarland, Leanne ;
Ogasawara, Annie ;
Williams, Simon ;
Cole, Mary J. ;
Ross, Sarajane ;
Schwall, Ralph .
CANCER RESEARCH, 2007, 67 (01) :254-261
[10]   PHASE-1 IMMUNOLYMPHOSCINTIGRAPHY WITH AN IN-111 LABELED ANTIMELANOMA MONOCLONAL-ANTIBODY [J].
ENGELSTAD, BL ;
SPITLER, LE ;
DELRIO, MJ ;
RAMOS, EC ;
ROSENDORF, LL ;
REINHOLD, CE ;
KHENTIGAN, A ;
HUBERTY, JP ;
CORPUZ, SW ;
LEE, HM ;
OKERLUND, MD ;
HATTNER, RS ;
SCANNON, PJ .
RADIOLOGY, 1986, 161 (02) :419-422