Effects of ethanol and nomifensine on NE clearance in the cerebellum of young and aged Fischer 344 rats

被引：13
作者：
Lin, AMY
Bickford, PC
Palmer, MR
Cline, EJ
Gerhardt, GA
机构：
[1] UNIV COLORADO,HLTH SCI CTR,DEPT PSYCHIAT,DENVER,CO 80262
[2] UNIV COLORADO,HLTH SCI CTR,DEPT PHARMACOL,DENVER,CO 80262
[3] ACAD SINICA,INST BIOMED SCI,TAIPEI,TAIWAN
[4] DEPT VET AFFAIRS MED CTR,DENVER,CO 80220
[5] UNIV COLORADO,HLTH SCI CTR,NEUROSCI TRAINING PROGRAM,DENVER,CO 80262
[6] UNIV COLORADO,HLTH SCI CTR,ROCKY MT CTR SENSOR TECHNOL,DENVER,CO 80262
来源：
BRAIN RESEARCH | 1997年 / 756卷 / 1-2期
关键词：
norepinephrine; ethanol; nomifensine; uptake; age; cerebellar cortex; Fischer; 344; rat; ACID-INDUCED DEPRESSIONS; PURKINJE-CELL RESPONSES; NUCLEUS-ACCUMBENS; DORSAL STRIATUM; DOPAMINE CLEARANCE; EXOGENOUS DOPAMINE; BRAIN; NOREPINEPHRINE; DIFFUSION; NEURONS;
D O I：
10.1016/S0006-8993(97)00229-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rapid chronoamperometric recordings coupled with local application of drugs by pressure ejection were used to investigate the effects of nomifensine and ethanol (EtOH) on exogenous norepinephrine (NE) clearance in the cerebellum of young (5-month-old) and aged (24-26-month-old) male Fischer 344 rats. In the young rats, local nomifensine application prolonged exogenous NE clearance, indicating transporter mediated uptake inhibition. NE clearance was modestly but significantly prolonged in the aged rats as compared to the young rats, suggesting less efficient uptake. Consistent with this, there was little effect of nomifensine on NE clearance in the aged rats. In contrast to the effect of nomifensine, EtOH inhibited NE clearance in both young and aged rats. These data further support the hypothesis that one effect of EtOH in cerebellar NE systems is inhibition of NE uptake into NE-containing nerve terminals, and they also demonstrate that the effect of nomifensine on exogenous NE clearance in vivo in the cerebellum is altered by the aging process, while the effect of EtOH is not.
引用
收藏
页码：287 / 292
页数：6
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