Polymorphisms and asthma: potential interest in pharmacogenetics

被引：0

作者：

Devillier, P ^{[1
]}

Advenier, C ^{[1
]}

机构：

[1] CHU, Hop Maison Blanche, Pharmacol Lab, F-51092 Reims, France

来源：

REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE | 2002年 / 42卷 / 01期

关键词：

pharmacogenetics; asthma; beta(2)-agonists; anti-leukotrienes;

D O I：

10.1016/S0335-7457(01)00109-5

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The efficacy of drug therapy in asthma varies widely between patients. Inter-subject variability may be due to environmental factors, differences in patient compliance, biological variations involved in the mechanisms of the disease or in the mode of action of drugs, some of which may be genetic in origin. The study of genetic factors determining treatment response to a given drug defines pharmacogenetics, a science in its infancy at the dawn of this new millennium. In asthma, a comprehensive screen of genes likely to be important in determining treatment response has not yet been performed, This paper will review the recent data regarding two good examples of polymorphisms apparently determining treatment response to two classes of drugs, the beta(2)-agonists and the anti-leukotrienes (C) 2002 Editions scientifiques et medicales Elsevier SAS.

引用

页码：28 / 34

页数：7

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