Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates

被引：1
作者：
Top, Janetta [1 ]
Sinnige, Jan C. [1 ,9 ]
Brouwer, Ellen C. [1 ]
Werner, Guido [2 ]
Corander, Jukka [3 ,4 ,5 ]
Severin, Juliette A. [6 ]
Jansen, Rogier [7 ]
Bathoorn, E. [8 ]
Bonten, Marc J. M. [1 ]
Rossen, John W. A. [8 ]
Willems, Rob J. L. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands
[2] Robert Koch Inst, Wernigerode Branch, Dept Infect Dis, Div Nosocomial Pathogens & Antibiot Resistance, Wernigerode, Germany
[3] Univ Oslo, Dept Biostat, Fac Med, Oslo, Norway
[4] Univ Helsinki, Dept Math & Stat, Helsinki, Finland
[5] Wellcome Trust Sanger Inst, Infect Genom, Hinxton, Cambs, England
[6] Erasmus Univ, Med Ctr, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
[7] OLVG, Dept Med Microbiol, Amsterdam, Netherlands
[8] Univ Med Ctr Groningen, Dept Med Microbiol, Groningen, Netherlands
[9] Reg Lab Publ Hlth Haarlem, Haarlem, Netherlands
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 03期
基金：
欧洲研究理事会;
关键词：
Enterococcus faecium; genomic island; vanD type; vancomycin resistance; MOLECULAR CHARACTERIZATION; CONJUGATIVE ELEMENTS; GENE-CLUSTER; FAECALIS; CANADA; FLORA;
D O I：
10.1128/AAC.01793-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.
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页数：7
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