Polysaccharides isolated from Laminaria japonica attenuates gestational diabetes mellitus by regulating the gut microbiota in mice

被引：48
作者：
Lin, Huiting [1 ,2 ]
Zhang, Jiawen [2 ]
Li, Shiyang [2 ]
Zheng, Baodong [1 ,2 ]
Hu, Jiamiao [1 ,2 ]
机构：
[1] Minist Educ, Engn Res Ctr Fujian Taiwan Special Marine Food Pr, Fuzhou 350002, Fujian, Peoples R China
[2] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou, Fujian, Peoples R China
来源：
FOOD FRONTIERS | 2021年 / 2卷 / 02期
关键词：
gut microbiome; Laminaria japonica; polysaccharides; METABOLIC SYNDROME; FUCOIDAN; RATS;
D O I：
10.1002/fft2.79
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The current study was aimed to explore the beneficial effects of polysaccharides isolated from Laminaria japonica (LP) on gestational diabetes mellitus (GDM) mice. The obtained results demonstrated that the LP improved serum biochemical index, body weight index, and glucose tolerance. Furthermore, the evidence also suggested that the beneficial effects of LP might be attributed to the alternation in gut microbiota by LP supplementation. Particularly, the Turicibacter, a short-chain fatty acids-producing bacterium, was found to be up-regulated. In conclusion, the obtained results indicated that the LP might serve as prebiotic, and might have a great potential to be used as food supplementation for GDM patients.
引用
收藏
页码：208 / 217
页数：10
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