Asymmetric Chlorination of 4-Substituted Pyrazolones Catalyzed by Chiral Copper Complexes

被引：8

作者：

Chen, Xue-Yang ^{[1
]}

Jiang, Zhen-Hui ^{[1
]}

Ju, Wan-Zhen ^{[1
]}

Yin, Hao ^{[1
]}

Qi, Suo-Suo ^{[1
]}

Chu, Ming-Ming ^{[1
]}

Wang, Yi-Feng ^{[1
]}

机构：

[1] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Key Lab Green Pesticides & Cleaner Prod Technol Z, Hangzhou 310014, Peoples R China

来源：

SYNLETT | 2020年 / 31卷 / 13期

基金：

国家重点研发计划;

关键词：

asymmetric catalysis; copper catalysis; bisoxazolines; chlorination; pyrazolones; BETA-KETO-ESTERS; ENANTIOSELECTIVE SYNTHESIS; PYRAZOLINONE KETIMINES; MICHAEL ADDITION; DERIVATIVES; CONSTRUCTION; FLUORINATION; ANNULATION; PYRAZOLIN-5-ONES; PYRAZOL-5-ONES;

D O I：

10.1055/s-0039-1690879

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fast and highly enantioselective chlorination of 4-pyrazolones catalyzed by bis(oxazoline)-Cu(ClO4)(2)center dot 6H(2)O complexes has been developed. Under the optimized conditions, a series of pyrazolones bearing stereogenic chlorine-attached carbon centers were obtained in moderate to high yields (up to 98%) and with enantioselectivities of up to 98% ee.

引用

页码：1318 / 1322

页数：5

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