Autotaxin in liver fibrosis

被引：58

作者：

Ikeda, Hitoshi ^{[1
]}

Yatomi, Yutaka ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Clin Lab Med, Bunkyo Ku, Tokyo 1138655, Japan

来源：

CLINICA CHIMICA ACTA | 2012年 / 413卷 / 23-24期

关键词：

Autotaxin; Lysophospholipase D; Liver fibrosis; Lysophosphatidic acid; HEPATIC STELLATE CELLS; PLASMA LYSOPHOSPHATIDIC ACID; HUMAN HEPATOCELLULAR-CARCINOMA; SINUSOIDAL ENDOTHELIAL-CELLS; HUMAN SERUM SAMPLES; LYSOPHOSPHOLIPASE-D; GLIOBLASTOMA-MULTIFORME; RHO-KINASE; RAT; EXPRESSION;

D O I：

10.1016/j.cca.2012.07.014

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Autotaxin (ATX) hydrolyzes lysophosphatidylcholine to produce lysophosphatidic acid (LPA), a multi-functional bioactive lipid mediator. ATX is a major determinant of LPA levels in the blood, and the pathophysiological functions of ATX are thought to be largely attributed to its ability to produce LPA. Liver fibrosis is one of the rare disorders exhibiting the increased ATX and LPA levels in the blood. This review summarizes the recent findings on the relation between ATX or LPA and liver fibrosis, the usefulness of serum ATX levels to predict the stages of liver fibrosis, and speculated roles of increased serum ATX and plasma LPA levels in liver fibrosis. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1817 / 1821

页数：5

共 56 条

[31] Lysophospholipids in the limelight: autotaxin takes center stage [J].

Moolenaar, WH .

JOURNAL OF CELL BIOLOGY, 2002, 158 (02) :197-199

[32]

MURO H, 1993, AM J PATHOL, V143, P105

[33] Autotaxin as a novel serum marker of liver fibrosis [J].

Nakagawa, Hayato ;

Ikeda, Hitoshi ;

Nakamura, Kazuhiro ;

Ohkawa, Ryunosuke ;

Masuzaki, Ryota ;

Tateishi, Ryosuke ;

Yoshida, Haruhiko ;

Watanabe, Naoko ;

Tejima, Kazuaki ;

Kume, Yukio ;

Iwai, Tomomi ;

Suzuki, Atsushi ;

Tomiya, Tomoaki ;

Inoue, Yukiko ;

Nishikawa, Takako ;

Ohtomo, Natsuko ;

Tanoue, Yasushi ;

Omata, Masao ;

Igarashi, Koji ;

Aoki, Junken ;

Koike, Kazuhiko ;

Yatomi, Yutaka .

CLINICA CHIMICA ACTA, 2011, 412 (13-14) :1201-1206

[34] Specific increase in serum autotaxin activity in patients with pancreatic cancer [J].

Nakai, Yousuke ;

Ikeda, Hitoshi ;

Nakamura, Kazuhiro ;

Kume, Yukio ;

Fujishiro, Mitsuhiro ;

Sasahira, Naoki ;

Hirano, Kenji ;

Isayama, Hiroyuki ;

Tada, Minoru ;

Kawabe, Takao ;

Komatsu, Yutaka ;

Omata, Masao ;

Aoki, Junken ;

Koike, Kazuhiko ;

Yatomi, Yutaka .

CLINICAL BIOCHEMISTRY, 2011, 44 (8-9) :576-581

[35] Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome [J].

Nakamura, Kazuhiro ;

Nangaku, Masaomi ;

Ohkawa, Ryunosuke ;

Okubo, Shigeo ;

Yokota, Hiromitsu ;

Ikeda, Hitoshi ;

Aoki, Junken ;

Yatomi, Yutaka .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2008, 46 (01) :150-151

[36] Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation [J].

Nakamura, Kazuhiro ;

Igarashi, Koji ;

Ide, Kazuftimi ;

Ohkawa, Ryunosuke ;

Okubo, Shigeo ;

Yokota, Hiromitsu ;

Masuda, Akiko ;

Oshima, Noriko ;

Takeuchi, Takumi ;

Nangaku, Masaomi ;

Okudaira, Shinichi ;

Arai, Hiroyuki ;

Ikeda, Hitoshi ;

Aoki, Junken ;

Yatomi, Yutaka .

CLINICA CHIMICA ACTA, 2008, 388 (1-2) :51-58

[37] Measurement of lysophospholipase D/autotaxin activity in human serum samples [J].

Nakamura, Kazuhiro ;

Ohkawa, Ryunosuke ;

Okubo, Shigeo ;

Tozuka, Minoru ;

Okada, Mitsumasa ;

Aoki, Shinya ;

Aoki, Junken ;

Arai, Hiroyuki ;

Ikeda, Hitoshi ;

Yatomi, Yutaka .

CLINICAL BIOCHEMISTRY, 2007, 40 (3-4) :274-277

[38] ACTIVATION-DEPENDENT CONTRACTILITY OF RAT HEPATIC LIPOCYTES IN CULTURE AND IN-VIVO [J].

ROCKEY, DC ;

HOUSSET, CN ;

FRIEDMAN, SL .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (04) :1795-1804

[39] Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy [J].

Shiratori, Y ;

Imazeki, F ;

Moriyama, M ;

Yano, M ;

Arakawa, Y ;

Yokosuka, O ;

Kuroki, T ;

Nishiguchi, S ;

Sata, M ;

Yamada, G ;

Fujiyama, S ;

Yoshida, H ;

Omata, M .

ANNALS OF INTERNAL MEDICINE, 2000, 132 (07) :517-524

[40] Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization [J].

Stassar, MJJG ;

Devitt, G ;

Brosius, M ;

Rinnab, L ;

Prang, J ;

Schradin, T ;

Simon, J ;

Petersen, S ;

Kopp-Schneider, A ;

Zöller, M .

BRITISH JOURNAL OF CANCER, 2001, 85 (09) :1372-1382

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