Topical therapies for skin cancer and actinic keratosis

被引：41

作者：

Haque, Tasnuva ^{[1
]}

Rahman, Khondaker M. ^{[2
]}

Thurston, David E. ^{[2
]}

Hadgraft, Jonathan ^{[1
]}

Lane, Majella E. ^{[1
]}

机构：

[1] UCL Sch Pharm, Dept Pharmaceut, London WC1N 1AX, England

[2] Kings Coll London, Inst Pharmaceut Sci, London SE1 1DB, England

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2015年 / 77卷

关键词：

Skin; Cancer; Actinic keratosis; Melanoma; Topical; Formulation; SQUAMOUS-CELL CARCINOMA; INGENOL MEBUTATE GEL; PENETRATION ENHANCERS; DRUG-DELIVERY; PHYSICOCHEMICAL CHARACTERIZATION; PERCUTANEOUS-ABSORPTION; TRANSDERMAL DELIVERY; DOUBLE-BLIND; 5-FLUOROURACIL; PERMEATION;

D O I：

10.1016/j.ejps.2015.06.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The global incidence of skin cancer and actinic keratosis (AK) has increased dramatically in recent years. Although many tumours are treated with surgery or radiotherapy topical therapy has a place in the management of certain superficial skin neoplasms and AK. This review considers skin physiology, non-melanoma skin cancer (NMSC), the relationship between AK and skin cancer and drugs administered topically for these conditions. The dermal preparations for management of NMSC and AK are discussed in detail. Notably few studies have examined drug disposition in cancerous skin or in AK. Finally, recent novel approaches for targeting of drugs to skin neoplasms and AK are discussed. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：279 / 289

页数：11

共 109 条

[1]

Ackerman A.B., 1985, KAPOSIS SARCOMA, P71

[2] CLINICAL-EVALUATION OF TOPICAL ISOTRETINOIN IN THE TREATMENT OF ACTINIC KERATOSES [J].

ALIREZAI, M ;

DUPUY, P ;

AMBLARD, P ;

KALIS, B ;

SOUTEYRAND, P ;

FRAPPAZ, A ;

SENDAGORTA, E .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1994, 30 (03) :447-451

[3] Kaposi's sarcoma [J].

Antman, K ;

Chang, Y .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (14) :1027-1038

[4] Genetics of familial melanoma: 20 years after CDKN2A [J].

Aoude, Lauren G. ;

Wadt, Karin A. W. ;

Pritchard, Antonia L. ;

Hayward, Nicholas K. .

PIGMENT CELL & MELANOMA RESEARCH, 2015, 28 (02) :148-160

[5] CONTRIBUTIONS OF DRUG SOLUBILIZATION, PARTITIONING, BARRIER DISRUPTION, AND SOLVENT PERMEATION TO THE ENHANCEMENT OF SKIN PERMEATION OF VARIOUS COMPOUNDS WITH FATTY-ACIDS AND AMINES [J].

AUNGST, BJ ;

BLAKE, JA ;

HUSSAIN, MA .

PHARMACEUTICAL RESEARCH, 1990, 7 (07) :712-718

[6] Final Version of 2009 AJCC Melanoma Staging and Classification [J].

Balch, Charles M. ;

Gershenwald, Jeffrey E. ;

Soong, Seng-jaw ;

Thompson, John F. ;

Atkins, Michael B. ;

Byrd, David R. ;

Buzaid, Antonio C. ;

Cochran, Alistair J. ;

Coit, Daniel G. ;

Ding, Shouluan ;

Eggermont, Alexander M. ;

Flaherty, Keith T. ;

Gimotty, Phyllis A. ;

Kirkwood, John M. ;

McMasters, Kelly M. ;

Mihm, Martin C., Jr. ;

Morton, Donald L. ;

Ross, Merrick I. ;

Sober, Arthur J. ;

Sondak, Vernon K. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (36) :6199-6206

[7] Structure and function of the epidermis related to barrier properties [J].

Baroni, Adone ;

Buommino, Elisabetta ;

De Gregorio, Vincenza ;

Ruocco, Eleonora ;

Ruocco, Vincenzo ;

Wolf, Ronni .

CLINICS IN DERMATOLOGY, 2012, 30 (03) :257-262

[8] Sun Exposure, Sunbeds and Sunscreens and Melanoma. What Are the Controversies? [J].

Bataille, Veronique .

CURRENT ONCOLOGY REPORTS, 2013, 15 (06) :526-532

[9] Trends in incidence of skin basal cell carcinoma. Additional evidence from a UK primary care database study [J].

Bath-Hextall, Fiona ;

Leonardi-Bee, Jo ;

Smith, Chris ;

Meal, Andy ;

Hubbard, Richard .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (09) :2105-2108

[10]

Benson H.A.E., 2012, TRANSDERMAL TOPICAL, P3

← 1 2 3 4 5 6 7 8 9 10 →