Vitamin D, the placenta and pregnancy

被引：150
作者：
Liu, N. Q.
Hewison, M. [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Orthopaed Surg, Los Angeles, CA 90095 USA
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 523卷 / 01期
关键词：
Vitamin D; Preeclampsia; Preterm birth; Placenta; Decidua; VDR; CYP27B1; CYP24A1; D-BINDING PROTEIN; 25-HYDROXYVITAMIN D CONCENTRATIONS; CALCIUM-REGULATING HORMONES; CHILDHOOD BONE MASS; CD4(+) T-CELLS; D-DEFICIENCY; D-RECEPTOR; 1,25-DIHYDROXYVITAMIN D-3; D SUPPLEMENTATION; D INSUFFICIENCY;
D O I：
10.1016/j.abb.2011.11.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Impaired vitamin D status is common to many populations around the world. However, data suggest that this is a particular problem for specific groups such as pregnant women. This has raised important questions concerning the physiological and clinical impact of low vitamin D levels during pregnancy, with implications for classical skeletal functions of vitamin D, as well as its diverse non-classical actions. The current review will discuss this with specific emphasis on the classical calciotropic effects of vitamin D as well as the less well established immunological functions of vitamin D that may influence pregnancy outcome. The review also describes the pathways that are required for metabolism and function of vitamin D, and the various clinical complications that have been linked to impaired vitamin D status during pregnancy. (C) 2011 Elsevier Inc. All rights reserved.
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页码：37 / 47
页数：11
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